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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (01): 109-111. 上一篇    下一篇

研究简报

一种使用1,3-二溴-5,5-2甲基苯乙酮α-溴代新方法

高国锐 管细霞 邹新琢*   

  1. (华东师范大学化学系 上海 200062)
  • 收稿日期:2006-01-21 修回日期:2006-04-26 发布日期:2006-12-30
  • 通讯作者: 邹新琢

A Novel Method for α-Bromination of Acetophenones Using 1,3-Dibromo-5,5-dimethylhydantoin

GAO Guo-Rui,GUAN Xi-Xia,ZOU Xin-Zhuo*   

  1. (Department of Chemistry, East China Normal University, Shanghai 200062, China)
  • Received:2006-01-21 Revised:2006-04-26 Published:2006-12-30
  • Contact: ZOU Xin-Zhuo

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报道了使用1,3-二溴-5,5-二甲基海因和对甲苯磺酸在甲醇中和20～60 ℃的温和条件下合成α-溴代苯乙酮的新方法. 对位和间位取代的苯乙酮获得了高的产率; 而在同样条件下, 邻位硝基苯乙酮没有发生反应.

关键词: 1,3-二溴-5,5-二甲基海因, α-溴代, 苯乙酮

A novel method for the synthesis of α-bromoacetophenones by the reaction of 1,3-di-bromo- 5,5-dimethylhydantoin with p-toluenesulfonic acid in methanol at 20～60 ℃ was described. Substituted acetophenones at the para or meta position of aromatic ring gave α-bromoacetophenones in high yield. However reaction of o-nitroacetophenone did not take place under the same condition.

Key words: 1,3-dibromo-5,5-dimethylhydantoins, acetophenone, α-bromination