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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (11): 1462-1464. 上一篇    下一篇

研究简报

1-β-D-呋喃核糖基-1,2,4-三唑-3-酰胺铂配合物的合成研究

孙莉，裴文*   

  1. (浙江工业大学化学工程与材料学院 杭州 310014)
  • 收稿日期:2005-04-13 修回日期:2005-05-23 发布日期:2005-10-30
  • 通讯作者: 裴文

Synthesis of Platinum Complexes with 1-β-D-Ribofuranosyl-1,2,4- triazole-3-carboxamide

SUN Li,PEI Wen*   

  • Received:2005-04-13 Revised:2005-05-23 Published:2005-10-30
  • Contact: PEI Wen

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cis-[Pt(DMSO)2Cl2], K[Pt(DMSO)Cl3]分别与两摩尔1-β-D-呋喃核糖基-1,2,4-三唑-3-酰胺(Ribavirin)进行络合反应, 制得了高收率的二配位铂配合物; 讨论了不同摩尔的1-β-D-呋喃核糖基-1,2,4-三唑-3-酰胺与cis-[Pt(DMSO)2Cl2]和K[Pt(DMSO)Cl3]进行络合反应的结果; 对[Pt (N4,N7-Ribavirin)(DMSO)Cl]配合物(1)的X衍射晶体结构进行了测定.

关键词: 铂金属络合物, 呋喃核糖基三唑酰胺, 合成

The X-ray structure of platinum complexes of [Pt(N4,N7-Ribavirin)(DMSO)Cl] was reported. The reactions of cis-[Pt(DMSO)2Cl2] and K[Pt(DMSO)Cl3] with various equivalents of 1-β-D-ribofuranosyl- 1,2,4-triazole-3-carboxamide were performed with good yields. The different results of such reaction were discussed.

Key words: platinum complexes, synthesis, ribavirin