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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (05): 526-531. 上一篇    下一篇

综述与进展

2-脱氧-L-核糖的合成方法研究概况

韩素辉，渠桂荣*，李永   

  1. (河南师范大学化学与环境科学院 新乡 453007)
  • 收稿日期:2004-08-05 修回日期:2004-11-04 发布日期:2004-04-30
  • 通讯作者: 渠桂荣

Review of the Synthetic Methods of 2-Deoxy-L-ribose

HAN Su-Hui,QU Gui-Rong*,LI Yong   

  1. (College of Chemical & Environmental Science, Henan Normal University, Xinxiang 453007)
  • Received:2004-08-05 Revised:2004-11-04 Published:2004-04-30
  • Contact: QU Gui-Rong

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综述了2-脱氧-L-核糖的合成方法概况: (1)五碳糖的还原脱氧; (2)六碳糖的降解脱氧; (3) α,β-不饱和内酯的非对映选择性加成; (4)高立体选择性的小分子间缩合; (5)不对称环氧化. 并重点讨论了五碳糖还原脱氧合成法的机理和改进的方法.

关键词: 2-脱氧-L-核糖, 合成方法, 降解脱氧, 不对称环氧化, 立体选择性

The synthetic methods of 2-deoxy-L-ribose were reviewed as follows: (1) reductive deoxygenation of pentose, (2) degradative deoxygenation of hexose, (3) diastereoselective addition of α,β-unsaturated lactone, (4) stereoselective condensation of small molecules, and (5) asymmetric epoxidation. The mechanism of reductive deoxygenation of pentose and the modified procedure were discussed in detail.

Key words: 2-deoxy-L-ribose, degradative deoxygenation, asymmetric epoxida-tion, stereoselection, synthesis