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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (02): 244-249. 上一篇    下一篇

研究论文

新型含1,2,4三唑基的1,5苯并硫氮杂的合成和表征

杨德保，刘方明*，沈松伟，陈盛钦   

  1. (杭州师范大学材料与化学化工学院 杭州 310036)
  • 收稿日期:2008-11-21 修回日期:2009-01-03 发布日期:2010-02-20

Synthesis and Characterization of Novel 3-(1,2,4-Triazol-1-yl)-1,5- benzo[b]thiazepine Derivatives

Yang Debao Liu Fangming* Shen Songwei Chen Shengqin   

  1. (College of Materials and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036)
  • Received:2008-11-21 Revised:2009-01-03 Published:2010-02-20

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以α-溴代苯乙酮为原料, 在三乙胺作用下制备α-(1,2,4-三唑-1-基)-芳基乙酮(1a～1c), 再与芳香醛发生羟醛缩合反应制备相应的含三唑基的查尔酮2a～2l, 将中间体2a～2l同邻氨基硫酚合成新型的2,4-二芳基-3-(1,2,4-三唑-1-基)-2,3-二氢-1,5-苯并硫氮杂(3a～3l). 所得化合物的结构经元素分析, IR, MS和1H NMR确认, 同时用X射线衍射法测定了化合物2a和3a的晶体结构.

关键词: 查尔酮, 1,2,4-三唑, 1,5-苯并硫氮杂, 晶体结构

The chalcones 2a～2l were synthesized by aldol condensation reaction of arylaldehydes with 1-aryl-2-(1H-1,2,4-triazol-1-yl)ethanones (1a～1c), which were prepared from 2-bromo-1-arylethanones. Then the intermediates 2a～2l were reacted with 2-aminobenzenethiol to give a series of 3-(1,2,4-triazol-1-yl)- benzo[b]thiazepine derivatives 3a～3l. Compounds 3a～3l were confirmed by means of elemental analysis, IR, 1H NMR, MS techniques, and compounds 2a and 3a were analyzed by X-ray single-crystal diffraction.

Key words: chalcone, 1,2,4-triazole, 1,5-benzo[b]thiazepine, crystal structure