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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (05): 662-674. 上一篇    下一篇

综述与进展

α-氰醇的生物催化合成新进展

陈沛然*，颜超，张怡   

  1. (东华大学化学化工与生物工程学院 上海 201620)
  • 收稿日期:2009-10-25 修回日期:2010-01-29 发布日期:2010-03-30
  • 通讯作者: 陈沛然 E-mail:prchen@dhu.edu.cn
  • 基金资助:

    国家级.国家自然科学基金

Recent Advances in the Bio-catalytic Synthesis of α-Cyanohydrins

CHEN Pei-Ran, YAN Chao, ZHANG Yi   

  1. (College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620)
  • Received:2009-10-25 Revised:2010-01-29 Published:2010-03-30
  • Contact: Chen Pei-Ran E-mail:prchen@dhu.edu.cn

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总结了近10年来生物催化不对称合成α-氰醇的新进展. 分别介绍了对羟腈裂解酶催化机理的新表述、反应体系(包括对酶的改造、反应介质、反应器)的新研究以及一系列醛(酮)的氢氰化反应.

关键词: α-氰醇, 生物催化, 羟腈裂解酶, 不对称氢氰化反应, 反应机理

Recent advances in the bio-catalytic synthesis of α-cyanohydrins are reviewed. New descriptions of HNL (hydroxynitrile lyase) catalytic mechanism, new investigation in the reaction system (including the modification of HNL, reaction media, and reactor), as well as the hydrocyanation of a series of aldehydes and ketones, which has not been reported in the prevenient reviews, are summarized.

Key words: α-cyanohydrins, bio-catalysis, hydroxynitrile lyase, asymmetric hydrocyanation, reaction mechanism