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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (12): 1949-1954. 上一篇    下一篇

研究简报

微波辐射下吲哚连噁二唑啉衍生物的合成和抗菌活性测定

赵志刚*，刘兴利，陈宇，李辉，石治川   

  1. (西南民族大学化学与环境保护工程学院 成都 610041)
  • 收稿日期:2010-05-07 修回日期:2010-06-30 发布日期:2010-07-23
  • 通讯作者: 赵志刚 E-mail:zzg63129@yahoo.com.cn
  • 基金资助:

    国家民委自然科学基金

Microwave-Assisted Synthesis of Oxadiazoline Derivatives Contain-ing Indole Structure and Their Antibacterial Activities

ZHAO Zhi-Gang, LIU Xing-Li, CHEN Yu, LI Hui, SHI Zhi-Chuan   

  1. (College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041)
  • Received:2010-05-07 Revised:2010-06-30 Published:2010-07-23
  • Contact: Zhi-Gang ZHAO E-mail:zzg63129@yahoo.com.cn

PDF

1093

被引次数

3

把噁二唑结构引入吲哚环中, 合成一类结构新颖的吲哚衍生物, 以期为新药筛选提供先导化合物. 在微波辐射条件下, 以较高的产率得到9个未见文献报道的新化合物, 其结构均经1H NMR, IR, MS及元素分析所证实, 并测试了化合物的抑菌活性.

关键词: 吲哚, 噁二唑, 微波辐射, 抗菌活性

A novel type of 6-substituted indole compounds has been designed and synthesized by connecting the structure of oxdiazoline to indole ring, with a view of providing lead compounds for the screening of new drugs. Under the condition of microwave irradiation, nine new compounds have been obtained with high yields, and the structures of all new compounds were characterized by IR, 1H NMR, MS techniques and elemental analysis. The antibacterial activities of compounds have been tested against two kinds of bacteria. The preliminary results showed that the compounds possess different inhibitive effects.

Key words: indole, oxdiazoline, microwave irradiation, antibacterial activity