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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (05): 653-658. 上一篇    下一篇

研究论文

氟化银促进烯炔分子内串联反应研究

唐建生*,1,2，谢叶香2，王志强2，李金恒*,2   

  1. (1湖南第一师范学院数理系 长沙 410205)
    (2湖南师范大学化学化工学院 化学生物学与中药分析教育部重点实验室 长沙 410081)
  • 收稿日期:2010-07-27 修回日期:2010-11-15 发布日期:2010-12-09
  • 通讯作者: 李金恒 E-mail:jhli@hunnu.edu.cn

Silver Fluoride-Promoted Intramolecular Cascade Reactions of Enynes

Tang Jiansheng*,1,2 Xie Yexiang2 Wang Zhiqiang2 Li Jinheng*,2   

  1. (1 Mathematics and Science Department, Hunan First Normal University, Changsha 410205)
    (2 Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), Hunan Normal University, Changsha 410081)
  • Received:2010-07-27 Revised:2010-11-15 Published:2010-12-09

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以烯炔为反应原料, 在碱性条件下, 顺利地发生分子内串联反应合成了芳基萘类木脂素. 研究发现, 加入氟化银可以高效地促进反应进行. 实验结果表明, 以CH2ClCH2Cl作溶剂, 在AgF和K2CO3存在下, 烯炔可以顺利发生分子内串联反应, 高产率得到芳基萘类木脂素.

关键词: 氟化银, 烯炔, 串联反应, 芳基萘类木脂素

Base-mediated intramolecular cascade reactions of enynes were carried out smoothly leading to arylnaphthalene lignan lactones. The results demonstrated that aryl-substituted enynes successfully underwent the intramolecular cascade reaction to afford the corresponding arylnaphthalene lignan lactones in moderate to excellent yields using AgF/K2CO3 mixture as the bases in CH2ClCH2Cl. It is noteworthy that silver fluoride can promote the intramolecular cascade reaction.

Key words: silver fluoride, enyne, cascade reaction, arylnaphthalene lignan lactone