有机化学 ›› 2011, Vol. 31 ›› Issue (08): 1324-1333. 上一篇    下一篇

学术动态

大黄素的化学合成及结构修饰研究进展

梁英1,喻大昭*,2   

  1. (1 湖北省农业科学院国家生物农药工程技术研究中心 武汉 430064)
    (2湖北省农业科学院农作物重大病虫草害防控湖北省重点实验室 武汉 430064)
  • 收稿日期:2010-12-31 修回日期:2011-02-17 发布日期:2011-03-16
  • 通讯作者: 梁英 E-mail:ly.liang8@gmail.com

Progress in Chemical Synthesis and Structural Modification of Emodin

Liang Ying1 Yu Dazhao*,2   

  1. (1 National Biopesticide Engineering Research Center, Hubei Academy of Agricultural Science, Wuhan 430064)
    (2Hubei Key Laboratory of Crop Diseases, Insect Pests and Weeds Control, Hubei Academy of Agricultural Science, Wuhan 430064)
  • Received:2010-12-31 Revised:2011-02-17 Published:2011-03-16
  • Contact: LIANG Ying E-mail:ly.liang8@gmail.com

大黄素是中药大黄的主要成分, 也存在于虎杖、芦荟等药用植物中, 是分布广泛的一种羟基蒽醌类化合物. 其药理作用表现为抗肿瘤、扩张血管、抗菌、导泻、利尿等, 具有很好的临床应用价值. 结合本研究组的工作综述了大黄素的化学合成方法、结构修饰和生物活性等方面的新进展.

关键词: 大黄素, 化学合成, 结构修饰, 进展

Emodin is a widespread hydroxylated anthraquinone and occurs in different Chinese herbs (rhubarb, aloe, polygonum). The pharmacological effects indicated that emodin showed anti-tumor, vasorelaxant, antibacterial, cathartic and diuretic activities and has a promising clinical value. In this paper, recent advances in the chemical synthesis, structural modification and biological activities of natural emodin derivatives are reviewed.

Key words: emodin, chemical synthesis, structural modification, progress