有机化学 ›› 2012, Vol. 32 ›› Issue (9): 1725-1731.DOI: 10.6023/cjoc1202231 上一篇    下一篇

研究简报

钌催化芳香硝基化合物和脂肪三级胺反应一锅法合成喹啉衍生物

杨辉琼a,b, 谌儒b, 邓国军b   

  1. a 湖南工程学院化学化工学院 湘潭 411104;
    b 湘潭大学化学学院 湘潭 411105
  • 收稿日期:2012-02-23 修回日期:2012-06-01 发布日期:2012-05-16
  • 通讯作者: 杨辉琼 E-mail:yanghuiqiong2996@126.com
  • 基金资助:

    国家自然科学基金(No.20902076)资助项目

Ruthenium-Catalyzed One-Pot Synthesis of Quinolines from Nitroarenes and Trialkylamines

Yang Huiqionga,b, Chen Rub, Deng Guojunb   

  1. a College of Chemistry and Chemical Engineering, Hunan Institute of Engineering, Xiangtan 411104;
    b College of Chemistry, Xiangtan University, Xiangtan 411105
  • Received:2012-02-23 Revised:2012-06-01 Published:2012-05-16
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.20902076)

以芳香硝基化合物和脂肪三级胺为原料,三环己基膦四氟硼酸盐为配体,在三氯化钌催化下“一锅法”合成了一系列喹啉衍生物.该法不需要添加任何额外的还原剂,原料便宜易得,操作工艺简单,产率中等.产物结构通过IR,1H NMR,13C NMR,MS以及元素分析表征.

关键词: C—N 键形成, 一锅法, 喹啉衍生物, 钌催化, 硝基芳烃, 三级胺

A series of quinolines were synthesized in moderate yields by one-pot reaction of nitroarenes and trialkylamines in the presence of a catalytic amount of ruthenium trichloride catalyst together with tricyclohexylphosphonium tetrafluoroborate ligand. This method is convenient without extra reductant, and nitroarenes are cheap and highly available. The structures of the products were characterized by IR,1H NMR,13C NMR, MS techniques and elemental analysis.

Key words: C—N bond formation, one-pot synthesis, quinolines, ruthenium catalyst, nitroarenes, trialkylamines