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有机化学
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有机化学 ›› 2012, Vol. 32 ›› Issue (9): 1732-1735.DOI: 10.6023/cjoc1202261 上一篇    下一篇

研究简报

微波辐射下离子液体催化一锅三组分反应合成 3-{1-[2-(4-芳基噻唑-2-基)亚肼基]乙基}香豆素

张冬暖a,b, 李记太a, 刘卉闵b, 宋亚丽c, 张英群b, 袁明月b   

  1. a 河北大学化学与环境科学学院 河北省分析科学技术重点实验室 保定 071002;
    b 河北农业大学理学院 保定 071001;
    c 河北大学药学院 保定 071001
  • 收稿日期:2011-02-26 修回日期:2012-06-01 发布日期:2012-05-12
  • 通讯作者: 李记太 E-mail:lijitai@hbu.cn
  • 基金资助:

    河北省科技厅(No.11276434)和保定市科技局(No.10ZF104)资助项目

Microwave-Assisted Ionic Liquid Catalyzed One-Pot Three-Component Synthesis of 3-{1-[2-(4-Arylthiazol-2-yl)-hydrazono]ethyl}-2H-chromen-2-one

Zhang Dongnuana,b, Li Jitaia, Liu Huiminb, Song Yalic, Zhang Yingqunb, Yuan Mingyueb   

  1. a Key Laboratory of Analyzed Science and Technology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002;
    b College of Science, Agricultural University of Hebei, Baoding 071001;
    c College of Pharmaceutical Sciences, Hebei University, Baoding 071002
  • Received:2011-02-26 Revised:2012-06-01 Published:2012-05-12
  • Supported by:

    Project supported by the Science and Technology Department of Hebei Province (No.11276434) and the Science and Technology Bureau of Baoding City (No.10ZF104)

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被引次数

7

在微波辐射下,以酸性离子液体甲基咪唑丙磺酸-三氟乙酸为催化剂,利用一锅法由乙酰香豆素、氨基硫脲和α-溴代芳乙酮三组分反应合成了系列3-{1-[2-(4-芳基噻唑-2-基)亚肼基]乙基}香豆素,反应时间短,操作简便,收率高(85%～95%),催化剂可回收循环使用,对环境友好.

关键词: 酸性离子液体, 3-{1-[2-(4-芳基噻唑-2-基)亚肼基]乙基}香豆素, 微波辐射, 合成

A series of 3-{1-[2-(4-arylthiazol-2-yl)hydrazono]ethyl}-2H-chromen-2-ones were synthesized with 85%～95% yields via the one-pot three-component reactions of acetyl coumarins, thiosemicarbazide and phenacyl bromide catalyzed by acidic ionic liquid under microwave irradiation. This method provides several advantages such as high yields, easy work-up and environmental friendly, and the catalyst can be recycled.

Key words: acidic ionic liquid, 3-{1-[2-(4-arylthiazol-2-yl)hydrazono]ethyl}-2H-chromen-2-one, microwave irradiation, synthesis