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有机化学
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有机化学 ›› 2012, Vol. 32 ›› Issue (10): 1999-2002.DOI: 10.6023/cjoc201204004 上一篇    下一篇

研究简报

无溶剂条件下简单、有效的合成多取代环己醇

荣良策a,b, 魏贤勇a, 路瑶a, 宗志敏 a   

  1. a 中国矿业大学化工学院 徐州 221008;
    b 江苏师范大学化学化工学院 徐州 221116
  • 收稿日期:2012-04-05 修回日期:2012-05-15 发布日期:2012-06-04
  • 通讯作者: 荣良策, 魏贤勇 E-mail:lcrong@jsnu.edu.cn or lcrong2005@yahoo.com
  • 基金资助:

    江苏省高校自然科学基础研究基金(No. 08KJB150017)和江苏师范大学科研平台(No. 10XLS02)资助项目.

A Facile and Efficient Synthesis of Polysubstituted Cyclohexanol Derivatives under Solvent-Free Conditions

Rong Liangcea,b, Wei Xianyonga, Lu Yaoa, Zong Zhimina   

  1. a School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008;
    b College of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116
  • Received:2012-04-05 Revised:2012-05-15 Published:2012-06-04
  • Supported by:

    Project supported by the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017) and the Foundation of Xuzhou Normal University (No. 10XLS02).

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被引次数

1

取代苯乙酮与查尔酮在氢氧化钠存在下于70 ℃加热反应, 取代苯乙酮与两分子查尔酮发生加成和环化反应, 生成了多取代环己醇. 本方法具有反应时间短、容易操作、产率高和环境友好等优点. 产物的结构经过红外、核磁和元素分析确定, 无溶剂方法是合成此类化合物的一条有效途径.

关键词: 查尔酮, 环己醇, 无溶剂反应, 迈克尔加成反应, 羟醛缩合

A facile and efficient synthesis of polysubstituted cyclohexanol derivatives by the addition and cyclization reaction of substituted acetophenone and chalcone in the presence of NaOH under solvent-free conditions is reported. This protocol has the advantages of shorter reaction time, mild conditions, easy work-up, and environmental friendliness. The products were identified by IR, 1H NMR and elemental analysis. The solvent-free method is the efficient approach for the synthesis of these compounds.

Key words: chalcone, cyclohexanol, solvent-free reaction, Michael addition, aldol condensations