有机化学 ›› 2012, Vol. 32 ›› Issue (10): 1988-1992.DOI: 10.6023/cjoc201204015 上一篇    下一篇

研究简报

化学与生物转化法合成帕立骨化醇

万阳, 文鹏, 张攀, 陆群   

  1. 西南交通大学生命科学与工程学院 成都 610031
  • 收稿日期:2012-04-12 修回日期:2012-06-06 发布日期:2012-06-19
  • 通讯作者: 陆群 E-mail:luqun1125@126.com
  • 基金资助:

    四川省科技支撑基金(No. 2010SZ124)资助项目.

Novel Synthesis of Paricalcitol by Chem-biotransformation

Wan Yang, Wen Peng, Zhang Pan, Lu Qun   

  1. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
  • Received:2012-04-12 Revised:2012-06-06 Published:2012-06-19
  • Supported by:

    Project supported by the Science and Technology Support Fundation of Sichuan Province (No. 2010SZ124).

以维生素D2 (1)为原料, 通过七步有机合成反应和一次生物转化, 成功获得了帕立骨化醇9, 并得到了一条新的合成帕立骨化醇的路线, 收率为3.24%. 该合成方法路线短, 操作简便, 收率较文献中的方法有较大提高. 所有产物结构经1H NMR, 13C NMR和MS表征.

关键词: 维生素D2, 羟基化, 帕立骨化醇

Paricalcitol (9) was obtained from Vitamin D2 via a route of the combination of seven-step organic reaction and biotransformation. The overall yield was 3.24%, which was higher than those of the reported methods. The structures of all intermediates and product were confirmed by 1H NMR, 13C NMR and MS techniques.

Key words: vitamin D2, hydroxylation, paricalcitol