有机化学 ›› 2016, Vol. 36 ›› Issue (11): 2743-2745.DOI: 10.6023/cjoc201605011 上一篇    下一篇

研究简报

一种新型科罗索酸衍生物的生物催化合成

付少彬a, 孟庆峰b, 辛庆a, 肖世基a   

  1. a 遵义医学院药学院 遵义 563000;
    b 遵义医学院公共卫生学院 遵义 563000
  • 收稿日期:2016-05-09 修回日期:2016-06-04 发布日期:2016-07-13
  • 通讯作者: 付少彬 E-mail:fushb@126.com
  • 基金资助:

    国家自然科学基金(No.21462057)、教育部春晖计划(No.Z2014091)、贵州省科技厅、遵义医学院、遵义市科技局联合基金(No.QKHLH-2014-7555)资助项目.

Biocatalytic Synthesis of a Novel Corosolic Acid Derivative

Fu Shaobina, Meng Qingfengbb, Xin Qingaa, Xiao Shijiaa   

  1. a School of Pharmacy, Zunyi Medical University, Zunyi 563000;
    b School of Public Health, Zunyi Medical University, Zunyi 563000
  • Received:2016-05-09 Revised:2016-06-04 Published:2016-07-13
  • Supported by:

    Project supported by the National Natural Sciences Foundation of China (No.21462057),the Program of Ministry of Education "Chunhui Plan" (No.Z2014091),and the United Fund of Guizhou Province,Zunyi Medical University and Zunyi City (No.QKHLH-2014-7555).

科罗索酸是一种五环三萜酸,因其显著的抗糖尿病活性而备受关注.通过生物催化的方法对其进行结构修饰和改造,增加科罗索酸结构多样性,为筛选结构新颖或活性更强衍生物奠定基础.使用一株植物内生真菌Umbelopsis is-abellina催化合成一个新的科罗索酸衍生物,命名为2α,3β,7β-三羟基-乌苏-11-烯-28,13-内酯(2).其结构通过高分辨质谱、核磁共振等波谱技术确定.

关键词: 科罗索酸, 生物催化, 羟基化, 2α,3β,7β-三羟基-乌苏-11-烯-28,13-内酯

Corosolic acid, a pentacyclic triterpene acid, attracted more and more attention because of the significant anti-diabetes activity. Biocatalysis was applied to modify the structure of corosolic acid to increase the structural diversity of corosolic acid and lay the foundation for screening derivatives with novel structure or better activity. A novel corosolic acid derivative was synthesized by endophytic fungus Umbelopsis isabellina. The structure of the new compound was established by HR-ESIMS and NMR spectrum.

Key words: corosolic acid, biocatalysis, hydroxylation, 2α,3β,7β-trihydroxy-urs-11-en-28,13-lactone