有机化学 ›› 2013, Vol. 33 ›› Issue (9): 1919-1931.DOI: 10.6023/cjoc201301051 上一篇    下一篇

综述与进展

吲哚与硝基烯的Friedel-Crafts反应的研究进展

王春超, 谢绍雷, 解正峰   

  1. 新疆大学化学化工学院 石油天然气精细化工教育部&新疆维吾尔自治区重点实验室 乌鲁木齐 830046
  • 收稿日期:2013-01-21 修回日期:2013-03-18 发布日期:2013-04-07
  • 通讯作者: 解正峰 E-mail:xiezhf72@yahoo.com.cn
  • 基金资助:

    国家自然科学基金(Nos. 21262034, 20962018, 20862015, 20562011)资助项目

Research Progress in Friedel-Crafts Reaction of Indoles and Nitroalkenes

Wang Chunchao, Xie Shaolei, Xie Zhengfeng   

  1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046
  • Received:2013-01-21 Revised:2013-03-18 Published:2013-04-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21262034, 20962018, 20862015, 20562011)

吲哚作为核心结构广泛存在于生物碱和药物中, 吲哚衍生物在生物体的生理活动中起着重要的作用, 其中吲哚和硝基烯的Friedel-Crafts是生成吲哚衍生物的重要方法. 按照反应中催化剂种类的不同分为: (1)无催化剂, (2)离子液体催化剂, (3)金属盐催化剂, (4)配合物催化剂, (5) Brønsted酸催化剂, (6)有机小分子催化剂, (7)其他类型催化剂. 对吲哚与硝基烯的Friedel-Crafts反应的情况进行了综述.

关键词: Friedel-Crafts反应, 吲哚, 硝基烯, 催化剂

Indoles, as the core structure, exist widely in many alkaloid natural products and pharmaceuticals. The derivatives of indole play an important role in organism physiological activities. The Friedel-Crafts reaction of indoles and nitroalkenes is an important method to generate indole derivatives. According to the kinds of the catalyst in the reaction, the Friedel-Crafts reactions of indoles and nitroalkenes were summarized in this paper as follows: (1) catalyst-free, (2) ionic liquid catalyst, (3) metal salt catalyst, (4) coordination compound catalyst, (5) Brønsted acid catalyst, (6) small molecular organic catalyst, (7) other catalysts.

Key words: Friedel-Crafts reaction, indole, nitroolefin, catalyst