有机化学 ›› 2014, Vol. 34 ›› Issue (5): 852-864.DOI: 10.6023/cjoc201312002 上一篇    下一篇

综述与进展

加兰他敏类生物碱的不对称合成研究进展

王海明a, 陈鹏b, 唐萌a   

  1. a 兰州大学药学院 兰州 730000;
    b 吉林大学化学学院 无机合成与制备化学国家重点实验室 长春 130012
  • 收稿日期:2013-12-02 修回日期:2014-01-07 发布日期:2014-02-10
  • 通讯作者: 陈鹏,唐萌 E-mail:pengchen@jlu.edu.cn
  • 基金资助:

    国家自然科学基金(No. 21302061)、中国博士后科学基金(Nos. 2013T60318,2012M510130)和吉林省科技发展计划(No. 20140520084JH)资助项目.

Progress in Asymmetric Synthesis of Galanthamine-Type Alkaloids

Wang Haiminga, Chen Pengb, Tang Menga   

  1. a School of Pharmacy, Lanzhou University, Lanzhou 730000;
    b State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012
  • Received:2013-12-02 Revised:2014-01-07 Published:2014-02-10
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21302061), the China Postdoctoral Science Foundation (Nos. 2013T60318, 2012M510130) and the Jilin Province Science and Technology Development Plan Item (No. 20140520084JH).

加兰他敏类生物碱是氢化二苯并呋喃类生物碱的重要组成部分. 它们独特的结构、良好的生物活性和前景广阔的药用价值吸引了众多化学家和药物学家的兴趣. 其合成难点是其中的含芳基手性全碳季碳的构筑. 本综述旨在阐述到目前为止加兰他敏类生物碱的不对称合成方法,根据合成路线中手性季碳的构筑方式分类进行说明,并尝试对每种合成方法进行评述.

关键词: 加兰他敏, 力可拉敏, 不对称合成, 手性全碳季碳

Galanthamine-type alkaloids are an important type of hydrodibenzofuran alkaloids. Their unique intriguing structures, significant biological activitives and pharmacological potential have attracted much attention of chemists and pharmacologists. The major challenge for their synthesis is how to construct the aryl-substituted all-carbon quaternary stereogenic center. In this paper, current strategies for asymmetric synthesis of galanthamine-type alkaloids are reviewed, and the different methods to prepare the quaternary carbon are discussed. The features of different strategies are also commented.

Key words: galanthamine, lycoramine, asymmetric synthesis, all-carbon quaternary stereogenic center