多组分反应在合成多取代咪唑类化合物中的应用

doi:10.6023/cjoc201412012

摘要/Abstract

多取代咪唑类化合物包括三取代咪唑和四取代咪唑, 在医药、化学传感及催化等领域有重要应用. 多组分反应作为原子经济性和反应选择性很高的一类反应, 广泛应用于多取代咪唑的合成中. 基于反应原料及方法进行分类, 综述了近年来利用多组分反应合成多取代咪唑类化合物的研究进展情况.

关键词: 三取代咪唑, 四取代咪唑, 多组分反应, 异相催化

Multi substituted imidazoles including tri- and tetra-substituted imidazoles, play important roles in the field of pharmaceutical, chemical sensing and catalysis etc. Multi-component reaction (MCR), a protocol with high atom economic and reaction selectivity, has been applied widly on the synthesis of multi-substituted imidazoles. Based on different starting materials and different methods, the recent advances in the synthesis of multi-substituted imidazols via multi-component reaction are reviewed.

Key words: tri-substituted imidazoles, tetra-substituted imidazoles, multi-component reaction, heterogeneous catalysis

引用此文

肖立伟, 彭晓霞, 周秋香, 寇伟, 时亚茹. 多组分反应在合成多取代咪唑类化合物中的应用[J]. 有机化学, 2015, 35(6): 1204-1215.

Xiao Liwei, Peng Xiaoxia, Zhou Qiuxiang, Kou Wei, Shi Yaru. Application of Multi-component Reaction in Synthesis of Multi- substituted Imidazoles[J]. Chin. J. Org. Chem., 2015, 35(6): 1204-1215.

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