过渡金属催化C—H键氟化反应研究进展

doi:10.6023/cjoc201512040

有机化学 ›› 2016, Vol. 36 ›› Issue (6): 1218-1228.DOI: 10.6023/cjoc201512040 上一篇下一篇

综述与进展

过渡金属催化C—H键氟化反应研究进展 2017-2018 Awarded

何将旗, 娄绍杰, 许丹倩

浙江工业大学催化加氢研究中心浙江省绿色农药清洁生产技术研究重点实验室杭州 310014

收稿日期:2015-12-26 修回日期:2016-01-25 发布日期:2016-02-18
通讯作者: 许丹倩 E-mail:chrc@zjut.edu.cn
基金资助:
国家自然科基金(No.21361130021)、中国博士后面上基金(No.2014M560494)以及浙江省博士后择优资助项目.

Recent Advances in Transition-Metal Catalyzed C—H Bond Fluorination

He Jiangqi, Lou Shaojie, Xu Danqian

Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology, Catalytic Hydrogenation Research Center, Zhejiang University of Technology, Hangzhou 310014

Received:2015-12-26 Revised:2016-01-25 Published:2016-02-18
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21361130021), the China Postdoctoral Science Foundation (No. 2014M560494) and the Postdoctoral Science Foundation of Zhejiang Province.

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摘要/Abstract

有机氟化物由于其特殊的性质被广泛应用于医药、农药以及材料领域中, 然而由于氟元素的强电负性使得引入氟原子充满了挑战. 过渡金属催化的碳氢键氟化反应由于其避免了使用预官能化的底物, 而且对自然界中最广泛存在的碳氢键进行直接活化官能化, 因此与传统的过渡金属催化的偶联反应相比在原子经济性、反应多样性以及环境友好性等方面都具有突出的优势. 近十年来, 利用过渡金属催化碳氢键氟化策略已经成为构建碳氟键重要手段和研究热点. 作者较全面地综述近年来过渡金属催化的碳氟键构建的研究进展及合成应用, 对该领域所存在的问题和局限性进行了总结, 并对今后的发展做了展望.

关键词: 过渡金属催化, 碳氢键活化, 氟化, 选择性, 导向基团

Organofluorine compounds are widely found in pharmaceuticals, agrochemicals, and materials due to their special properties. However, development of transformations to incorporate fluorine atom is usually a great challenge, because of its highly electronegative nature. Transition-metal catalyzed C—H bond fluorination has significant advantages in atom-economy, reaction diversity and environmental friendliness in comparison with the traditional transition-metal catalyzed cross-coupling approaches since it obviates the use of pre-functionalized substrates. In the past decade, C—H bond fluorination strategy has emerged as a powerful protocol to access new C—F bonds. This review presents the state of art for transition-metal catalyzed C—H bond fluorination. The existing problems and limitations of the field are summarized and the outlook of the area is also prospected.

Key words: transition-metal catalysis, fluorination, C—H bond activation, selective, directing groups

引用此文

何将旗, 娄绍杰, 许丹倩. 过渡金属催化C—H键氟化反应研究进展[J]. 有机化学, 2016, 36(6): 1218-1228.

He Jiangqi, Lou Shaojie, Xu Danqian. Recent Advances in Transition-Metal Catalyzed C—H Bond Fluorination[J]. Chin. J. Org. Chem., 2016, 36(6): 1218-1228.

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过渡金属催化C—H键氟化反应研究进展 2017-2018 Awarded

Recent Advances in Transition-Metal Catalyzed C—H Bond Fluorination

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