有机化学 ›› 2016, Vol. 36 ›› Issue (6): 1407-1411.DOI: 10.6023/cjoc201601010 上一篇    下一篇

研究简报

无溶剂熔融条件下5-[(3-吲哚基)-芳甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮类化合物的绿色合成

吕成伟, 刘妍杭, 周晓霞   

  1. 辽宁师范大学化学化工学院大连 116029
  • 收稿日期:2016-01-10 修回日期:2016-02-01 发布日期:2016-02-24
  • 通讯作者: 吕成伟 E-mail:chengweilv@126.com
  • 基金资助:

    国家自然科学基金(No.21403100)和辽宁省博士启动基金(No.20141100)资助项目.

Efficient and Green Synthesis of 5-[(Indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives in the Melt

Lü Chengwei, Liu Yanhang, Zhou Xiaoxia   

  1. Shcool of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029
  • Received:2016-01-10 Revised:2016-02-01 Published:2016-02-24
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21403100), and the Doctoral Scientific Research Foundation of Liaoning Province (No. 20141100).

报道了一种基于Yonemitsu反应的β-吲哚衍生物的绿色合成方法. 以醛、吲哚和麦氏酸为原料, 在无溶剂、熔融的条件下, 由微量的水促进三组分反应合成了16种5-[(3-吲哚基)-芳甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮类化合物, 产率为55%~94%. 该方法具有反应条件温和、操作简单、合成效率高和环境友好等优点.

关键词: 熔融法, 多组分反应, 水, β-吲哚衍生物, 绿色化学

An efficient melting method for the synthesis of β-indole derivatives via Yonemitsu reaction was developed successfully using aldehyde, indole and Meldrum's acid as the starting materials and 50 μL water as green promoter without other solvent. A series of 5-[(indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized in 55%~94% yields. The remarkable advantages of this reaction were mild reaction condition, easy operation, tolerant the substrates with diverse functional groups and environment-friendly.

Key words: melting method, multicomponent reaction, water, β-indole derivatives, green chemistry