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有机化学 ›› 2016, Vol. 36 ›› Issue (7): 1677-1680.DOI: 10.6023/cjoc201602002 上一篇    下一篇

研究简报

稀有植物四川金粟兰化学成分的进一步研究

王立军, 刘彩云, 熊娟, 胡金锋   

  1. 复旦大学药学院 上海 201203
  • 收稿日期:2016-02-01 修回日期:2016-03-04 发布日期:2016-03-28
  • 通讯作者: 胡金锋 E-mail:jfhu@fudan.edu.cn
  • 基金资助:

    国家自然科学基金（Nos.21472021，81273401，21575029）和国家重点基础研究发展计划（973计划，No.2013CB530700）资助项目.

Further Chemical Constituents from the Rare Chloranthaceae Plant Chloranthus sessilifolius

Wang Lijun, Lau Choiwan, Xiong Juan, Hu Jinfeng   

  1. School of Pharmacy, Fudan University, Shanghai 201203
  • Received:2016-02-01 Revised:2016-03-04 Published:2016-03-28
  • Supported by:

    Project supported by National Natural Science Foundation of China (Nos. 21472021, 81273401, 21575029) and the National Basic Research Program of China (973 Program, No. 2013CB530700).

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补充材料

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对稀有植物四川金粟兰（Chloranthus sessilifolius）全草甲醇提取物开展进一步化学成分研究，从中分离得到2个二萜类、1个苯丙素类、1个黄酮类和1个木脂素类化合物. 利用多种波谱和光谱技术（如红外、紫外、1D/2D NMR、ECD、HR-ESIMS）结合相关文献中的理化数据确定了它们的结构分别为：（3R，5S，6S，9S，10S，13S）-3，6，13-三羟基-对映松香烷-8（14）-烯-7-酮（1）、3α，15-二羟基-13α-甲氧基-对映松香烷-8（14）-烯-7-酮（2）、p-香豆酰-β-苯乙胺（3）、柚皮素三甲基醚（4）和（3R，4R，3'R，4'R）-6，6'-二甲氧基-3，4，3'，4'-四氢-2H，2H'-[3，3']-双色原烯-4，4'-二醇（5）. 其中，化合物1为新的对映松香烷型二萜，而3~5则均为首次从金粟兰属植物中分离得到的化合物.

关键词: 四川金粟兰, 金粟兰科, 化学成分, 对映松香烷二萜

Two diterpenoids and a few miscellaneous components (one phenethylpropanoid, one flavonoid, and one lignan) were isolated from the MeOH extract of the whole plant of the rare Chloranthaceae plant Chloranthus sessilifolius during a further phytochemical reinvestigation. Based on their spectroscopic data (i.e., IR, UV, 1D/2D NMR, ECD, and HR-ESIMS) and/or comparing with those reported physicochemical data in related literature, the structures were determined to be (3R,5S,6S,9S,10S,13S)-3,6,13-trihydroxy-ent-abieta-8(14)-en-7-one (1), 3α,15-dihydroxy-13α-methoxy-ent-abieta-8(14)-en-　7-one (2), p-coumaroyl-β-phenethyl amine (3), narigenin trimethyl ether (4), and (3R,4R,3'R,4'R)-6,6'-dimethoxy-3,4,3',4'-　tetrahydro-2H,2H'-[3,3']-bichromenyl-4,4'-diol (5). Among them, compound 1 is new, while compounds 3~5 were isolated from the Chloranthus genus for the first time.

Key words: Chloranthus sessilifolius, Chloranthaceae, chemical constituents, ent-abietane-type diterpenoids