分子内直接引入含氟基团以及18F-标记方法研究进展

doi:10.6023/cjoc201601009

摘要/Abstract

含氟基团拥有强吸电子性和高亲脂性，有机分子适当地引入含氟基团可以改善其原有的功能. 因此，向分子内引入含氟基团的方法成为了当前的研究热点. 由于三氟甲硫基拥有突出的性能，其引入方法成为主要研究热点之一，三氟甲硒基、三氟甲氧基以及三氟乙氧基的引入方法也受到了科研人员的关注. ¹⁸F拥有几乎理想的原子核性能，是临床成像使用最广泛的正电子发射断层显像（PET）放射性核素. 因此，新型[¹⁸F]放射性示踪剂的研发成为很多科研人员的研究方向. 研发新型[¹⁸F]放射性示踪剂的关键在于用¹⁸F对生物分子进行标记. 介绍了最近报道的向分子内直接引入CF₃X（X＝S，Se，O，CH₂O）基团的新方法以及一些¹⁸F-标记方法的研究成果. 此外，总结了一些该领域值得关注的研究方向.

关键词: 三氟甲硫基化, 三氟甲硒基化, 三氟甲氧基化, 三氟乙氧基化, ¹⁸F-标记

Fluorine-containing groups have strong electron-withdrawing effect and high lipophilicity, organic molecules incorporated fluorine-containing groups can improve its function. Therefore, the incorporation of fluorine-containing groups into molecules has become the current research hotspot. The method for incorporation of CF₃S group becomes one of the hot research field due to its excellent nature. The strategy for incorporation of CF₃Se, CF₃O and CF₃CH₂O groups has also been the attention of researchers. ¹⁸F has nearly ideal nuclear properties and is the most widely used positron emission tomography (PET) radioisotope for clinical imaging. Therefore, the development of new [¹⁸F]radiotracers becomes the research focus of many researchers. The method for ¹⁸F-labeling of biomolecules is the key to the development of new [¹⁸F]radiotracers. This paper mainly introduce the recently reported methodology of direct incorporating CF₃X (X＝S, Se, O, CH₂O) groups into molecules and some research results of ¹⁸F-labeling methods. Furthermore, some noteworthy research directions in this field are summarized.

Key words: trifluoromethylthiolation, trifluoromethylselenolation, trifluoromethyloxylation, trifluoroethoxylation, ¹⁸F-labeling

引用此文

李恭铭, 孙德群. 分子内直接引入含氟基团以及¹⁸F-标记方法研究进展[J]. 有机化学, 2016, 36(8): 1715-1740.

Li Gongming, Sun Dequn. Recent Advances of Direct Incorporation of Fluorine-Containing Groups and ¹⁸F-Labeling Methods[J]. Chin. J. Org. Chem., 2016, 36(8): 1715-1740.

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分子内直接引入含氟基团以及¹⁸F-标记方法研究进展

Recent Advances of Direct Incorporation of Fluorine-Containing Groups and ¹⁸F-Labeling Methods

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