直接三氟甲硫基化反应研究进展

doi:10.6023/cjoc201501017

摘要/Abstract

三氟甲硫基由于具有较强的吸电子性和极高的亲脂性, 使得含三氟甲硫基的化合物在医药、农药以及材料等领域发挥着重要的作用. 从有机氟化学的发展历程来看, 三氟甲硫基化反应是继三氟甲基化反应后的又一重要研究课题, 受到化学家的广泛关注. 重点论述了近5年来国内外学者在直接三氟甲硫基化反应的研究成果, 并讨论了三氟甲硫基化反应所面临的一些挑战.

关键词: 三氟甲硫基化, 有机氟化学, 氧化偶联

Compounds containing trifluoromethylthio group (SCF₃) play an important role in pharmaceuticals, agrochemicals and materials due to its strong electron-withdrawing effect and extremely high lipophilicity. Very recently, trifluoromethylthiolation has received a great attention. In this review, the new progress of direct trifluoromethylthiolation is described. Furthermore, the synthetic challenge for trifluoromethylthiolation is also discussed.

Key words: trifluoromethylthiolation, organofluorine chemistry, oxidative coupling

引用此文

张柯, 徐修华, 卿凤翎. 直接三氟甲硫基化反应研究进展[J]. 有机化学, 2015, 35(3): 556-569.

Zhang Ke, Xu Xiuhua, Qing Fengling. Recent Advances of Direct Trifluoromethylthiolation[J]. Chin. J. Org. Chem., 2015, 35(3): 556-569.

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