有机化学 ›› 2018, Vol. 38 ›› Issue (1): 124-130.DOI: 10.6023/cjoc201709054 上一篇    下一篇

所属专题: 庆祝吴养洁院士九十华诞专辑

研究论文

碘催化喹啉氮氧化物与磺酰肼的区域选择性磺酰化反应

余海洋, 皮超, 王勇, 崔秀灵, 吴养洁   

  1. 郑州大学化学与分子工程学院 河南省化学生物与有机化学重点实验室 河南省高等学校应用化学重点开放实验室 郑州 450052
  • 收稿日期:2017-09-30 修回日期:2017-11-14 发布日期:2017-11-15
  • 通讯作者: 崔秀灵 E-mail:cuixl@zzu.edu.cn
  • 基金资助:

    国家国际科技合作专项(No.2016YFE0132600)及河南省高校科技创新人才支持计划(No.16HASTIT007)资助项目.

Iodine-Catalyzed Regioselective Sulfonylation of Quinoline N-Oxides with Sulfonyl Hydrazides

Yu Haiyang, Pi Chao, Wang Yong, Cui Xiuling, Wu Yangjie   

  1. Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052
  • Received:2017-09-30 Revised:2017-11-14 Published:2017-11-15
  • Contact: 10.6023/cjoc201709054 E-mail:cuixl@zzu.edu.cn
  • Supported by:

    Project supported by the Ministry of Science and Technology of China (No. 2016YFE0132600) and the Science and Technology Innovation Program of Universities in Henan Province (No. 16HASTIT007).

发展了一种新型且简单的喹啉氮氧化合物的2位区域选择性磺酰化反应,此方法具有操作简单、高效能、环境友好、无金属添加等优势,脂肪和芳香磺酰肼都能以较好的收率得到2位磺酰化喹啉化合物.

关键词: 碘催化, 喹啉氮氧, 磺酰肼

A novel and simple protocol has been developed for the regioselective sulfonylation of quinolone N-oxides at their C-2 postition. This method features with a simple system, high efficiency, environmental friendliness, and metal-free conditions. Aliphatic and aryl sulfonyl hydrazides smoothly undergo sulfonylation with quinoline N-oxides in good yields.

Key words: iodine-catalyzed, quinoline N-oxides, sulfonyl hydrazides