磺酰肼和二硫缩烯酮区域选择性环化反应合成3-烷硫基取代吡唑

doi:10.6023/cjoc202005026

摘要/Abstract

以磺酰肼和二硫缩烯酮为起始物，在廉价易得的硫酸氢钠作为催化剂条件下，建立了二者之间区域选择性环化合成3-烷硫基取代的吡唑类化合物的方法.在1，4-二氧六环作为介质和80℃加热条件下进行，高效合成了一系列N-磺酰基结构的3-烷硫基吡唑化合物.

关键词: 二硫缩烯酮, 磺酰肼, 环化, 区域选择性, 3-烷硫基吡唑

By using sulfonyl hydrazines and ketene dithioacetals as starting materials, the regioselective annulation providing 3-alkylthiolated pyrazoles has been realized in the low cost and easily available NaHSO₄ catalytst. The reactions were realized in 1,4-dioxane medium and 80 ℃ heating, whereby a seris of 3-alkylthiol pyrazoles possessing N-sulfonyl structure have been efficiently synthesized.

Key words: ketene dithioacetal, sulfonyl hydrazine, annulation, regioselectivity, 3-alkylthiopyrazole

引用此文

李毅, 万结平. 磺酰肼和二硫缩烯酮区域选择性环化反应合成3-烷硫基取代吡唑[J]. 有机化学, 2020, 40(11): 3889-3894.

Li Yi, Wan Jieping. Synthesis of 3-Alkylthiol Pyrazoles via Regioselective Annulation Reactions of Sulfonyl Hydrazines and Ketene Dithioacetals[J]. Chinese Journal of Organic Chemistry, 2020, 40(11): 3889-3894.

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