有机化学 ›› 2019, Vol. 39 ›› Issue (12): 3467-3474.DOI: 10.6023/cjoc201907010 上一篇    下一篇

研究论文

Cu-Cu2O/GO-NH2催化的芳基丙炔酸脱羧氧膦酰化反应研究

钟文武a,b,c, 唐倩a,b,c, 杨宗发a,b, 曾雪a,b, 甘淋玲a,b, 兰作平a,b, 杨元娟a,b,c   

  1. a 重庆医药高等专科学校 重庆 401331;
    b 重庆市药物制剂工程技术研究中心 重庆 401331;
    c 国家中医药质量检测二级科研实验室 重庆 401331
  • 收稿日期:2019-07-04 修回日期:2019-08-13 发布日期:2019-08-30
  • 通讯作者: 兰作平, 杨元娟 E-mail:lanzuop@126.com;Yang_1889@sina.com
  • 基金资助:
    Project supported by the Scientific Research Project of Chongqing Medical and Pharmaceutical College (Nos. ygz2018303, ygz2018102), the Medical Scientific Research Project of Chongqing Municipal Health and Family Planning Commission (Nos. 2012-1-093, 20142116), the Chinese Medicine Science and Technology Project of Chongqing Municipal Health and Family Planning Commission (No. ZY201402158), and the Scientific and Technological Research Project of Chongqing Municipal Education Commission (No. KJ1726394).

Decarboxylative Oxyphosphorylation of Alkynyl Carboxylic Acids with H-Phosphonates Catalyzed by Cu-Cu2O/GO-NH2

Zhong Wenwua,b,c, Tang Qiana,b,c, Yang Zongfaa,b, Zeng Xuea,b, Gan Linlinga,b, Lan Zuopinga,b, Yang Yuanjuana,b,c   

  1. a Chongqing Medical and Pharmaceutical College, Chongqing 401331;
    b Chongqing Engineering Technology Research Center of Pharmaceutical Sciences, Chongqing 401331;
    c National Second-level Scientific Research Laboratory of the Quality Testing of Traditional Chinese Medicine, Chongqing 401331
  • Received:2019-07-04 Revised:2019-08-13 Published:2019-08-30
  • Supported by:
    Project supported by the Scientific Research Project of Chongqing Medical and Pharmaceutical College (Nos. ygz2018303, ygz2018102), the Medical Scientific Research Project of Chongqing Municipal Health and Family Planning Commission (Nos. 2012-1-093, 20142116), the Chinese Medicine Science and Technology Project of Chongqing Municipal Health and Family Planning Commission (No. ZY201402158), and the Scientific and Technological Research Project of Chongqing Municipal Education Commission (No. KJ1726394).

本研究开发一种铜纳米负载的氨基石墨烯(Cu-Cu2O/GO-NH2)作为多相催化剂用于合成β-羰基膦酸酯类化合物的新方法.与传统的均相催化相比,该方法可以实现催化剂的多次循环利用.该多相催化反应体系不需要添加任何碱和催化剂助剂,操作简单,催化活性高,底物适用范围广,为β-羰基膦酸酯类化合物的合成提供了可供选择的新策略.

关键词: 铜纳米粒子, 石墨烯, 氧膦酰化反应, 多相催化, β-羰基膦氧

A graphene based hybrid with copper nanoparticles (Cu-Cu2O/GO-NH2) as a heterogeneous catalyst for the preparation of β-ketophosphonates was investigated. Compared with traditional homogeneous catalysis, Cu-Cu2O/GO-NH2 catalyst can be recovered from the reaction system. The present methodology provides a facile and efficient approach to access a wide range of β-ketophosphonates in good yields. This reaction can be conducted under base-free conditions without any external co-catalysts, which provides an alternative strategy for the synthesis of β-ketophosphonates.

Key words: Cu nanoparticles, graphene, oxyphosphorylation, heterogeneous catalysis, β-ketophosphonates