有机化学 ›› 2020, Vol. 40 ›› Issue (1): 61-68.DOI: 10.6023/cjoc201905022 上一篇    下一篇

研究论文

钯催化二芳基膦氢对萘醌单酮的不对称1,4-加成反应

孙贵救a, 肖繁花a, 段伟良b   

  1. a 上海应用技术大学化学与环境工程学院 上海 200237;
    b 扬州大学化学化工学院 江苏扬州 225002
  • 收稿日期:2019-05-11 修回日期:2019-08-29 发布日期:2019-09-12
  • 通讯作者: 肖繁花, 段伟良 E-mail:fhxiao@sit.edu.cn;duanwl@yzu.edu.cn
  • 基金资助:
    国家自然科学基金(Nos.21472218,21672183)资助项目.

Palladium-Catalyzed Asymmetric 1,4-Addition of Diarylphosphines to Quinone Monoketals

Sun Guijiua, Xiao Fanhuaa, Duan Weiliangb   

  1. a School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418;
    b College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002
  • Received:2019-05-11 Revised:2019-08-29 Published:2019-09-12
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21472218, 21672183).

研究了二芳基膦氢和萘醌单酮的不对称加成反应,在Pincer钯催化剂存在下,以中等到良好的产率和对映选择性合成了相应的手性膦化合物,进一步拓宽了Pincer钯催化剂的底物应用范围.

关键词: 钯催化, 二芳基磷氢, 不对称加成

An asymmetric 1,4-addition reaction of diarylphosphines with quinone monoketals was studied. Pincer Pd complex was used as catalyst to generate a series of chiral phosphorus compounds with moderate to good enantioselectivities in high yields.

Key words: palladium catalysis, diarylphosphine, asymmetric addition