有机化学 ›› 2020, Vol. 40 ›› Issue (6): 1766-1771.DOI: 10.6023/cjoc202002002 上一篇    下一篇

研究简报

无金属条件下通过与醚的自由基偶联反应实现N-氧化物的C-2烷基化反应

董道青a, 李光辉a, 陈德茂a, 孙媛媛a, 韩晴晴a, 王祖利a, 徐鑫明b, 于贤勇c   

  1. 青岛农业大学化学与药学院 山东青岛 266109;
    烟台大学化学化工学院 山东烟台 264005;
    湖南科技大学化学化工学院 湖南湘潭 411201
  • 收稿日期:2020-02-01 修回日期:2020-03-01 发布日期:2020-03-06
  • 通讯作者: 王祖利 E-mail:wangzulichem@163.com
  • 基金资助:
    国家自然科学基金(No.21772107)、山东省重点研发计划(No.2019GSF108017)资助项目.

Metal-Free C-2 Alkylation of N-Oxides with Ethers via Radical Cross-Coupling Reactions

Dong Daoqinga, Li Guanghuia, Chen Demaoa, Sun Yuanyuana, Han Qingqinga, Wang Zulia, Xu Xinmingb, Yu Xianyongc   

  1. a College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, Shandong 266109;
    b College of Chemistry and Chemical Engineering, Yantai University, Yantai, Shandong 264005;
    c School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201
  • Received:2020-02-01 Revised:2020-03-01 Published:2020-03-06
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21772107), and the Shandong Provincal Key Research and Development Plan (No. 2019GSF108017).

在无金属条件下通过自由基偶联反应,实现了醚类与N-氧化物的C-2烷基化反应,反应条件温和,只需加入氧化剂二叔丁基过氧化物(DTBP)就能够以中等至高产率获得各种所需产物.

关键词: 喹啉-N-氧化物, 醚, 烷基化, 自由基偶联

The C-2 alkylation of ethers and N-oxides was achieved via free radical coupling reaction under metal-free conditions. The reaction conditions are mild, and the desired products can be obtained in medium to high yields with the addition of the oxidant di-tert-butyl peroxide (DTBP).

Key words: quinoline N-oxides, ethers, alkylation, radical cross