吡咯并吡咯二酮类光敏剂/光热试剂在肿瘤治疗中的应用研究进展

doi:10.6023/cjoc202005041

有机化学 ›› 2020, Vol. 40 ›› Issue (12): 4155-4167.DOI: 10.6023/cjoc202005041 上一篇下一篇

综述与进展

吡咯并吡咯二酮类光敏剂/光热试剂在肿瘤治疗中的应用研究进展

汪凌云, 辛舒琪, 唐浩, 曹德榕

华南理工大学化学与化工学院广州 510640

收稿日期:2020-05-18 修回日期:2020-06-17 发布日期:2020-07-09
通讯作者: 汪凌云 E-mail:lingyun@scut.edu.cn
基金资助:
国家自然科学基金（Nos.21772045，22071065）、广东省自然科学基金（No.2018B030311008）、中国留学基金委员会（No.201906155012）和广州市科技计划（No.201904010414）资助项目.

Research Progress in Cancer Treatment by Diketopyrrolopyrrole-Based Photosensitizers and Photothermal Agents

Wang Lingyun, Xin Shuqi, Tang Hao, Cao Derong

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640

Received:2020-05-18 Revised:2020-06-17 Published:2020-07-09
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21772045, 22071065), the Natural Science Foundation of Guangdong Province (No. 2018B030311008), the China Scholarship Council (No. 201906155012) and the Technology Program of Guangzhou City (No. 201904010414).

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摘要/Abstract

肿瘤的发病率呈逐年上升趋势，已成为威胁人类健康的第一大疾病.光疗（光动力疗法和光热疗法）作为一类新型的肿瘤治疗方式，具有创伤小、治疗周期短、毒副作用低、选择性好、无抗药性和免疫抑制等优点，受到了研究人员的广泛关注，并已被逐步应用于临床.作为光疗中至关重要的决定性因素，光敏剂和光热试剂的研究受到越来越多的重视.吡咯并吡咯二酮具有平面性好、电子亲和势强、合成简单、结构易修饰及摩尔吸光系数高等优点，是一种优异的光敏剂和光热试剂.从吡咯并吡咯二酮的结构改造、结构与性能关系、光疗作用机理等方面对近年来吡咯并吡咯二酮类光敏剂和光热试剂的研究现状进行了综述，并对其发展趋势进行了展望.

关键词: 吡咯并吡咯二酮, 光动力治疗, 光热治疗, 联合治疗

Cancer has become one of the major threats to human health in modern society. Phototherapy including photodynamic therapy (PDT) and photothermal therapy (PTT), as a new type of tumor treatment, has received more and more attentions due to its high spatiotemporal precision, noninvasive nature, controllability, low toxicity and repeatable treatment without initial resistance. It is important to obtain a highly efficient and ideal photosensitizer for reactive oxygen species (ROS) generation for PDT. Photothermal agents with high photothermal conversion efficiency are also in urgent need for PTT. Diketopyrrolopyrrole (DPP) is an excellent type of photosensitizer and photothermal reagent because of its good structural planarity, strong electron affinity, simple synthesis, easy structure modification and high molar absorption coefficient. The research progress of DPP-based photosensitizers and photothermal agents in recent year, including structural modification of DPP, the structure-activity relationship, the mechanism of phototherapy and some representative examples is summarized. Finally, a perspective on the future development of phototherapy based on DPP is presented.

Key words: diketopyrrolopyrrole, photodynamic therapy, photothermal therapy, combined therapy

引用此文

汪凌云, 辛舒琪, 唐浩, 曹德榕. 吡咯并吡咯二酮类光敏剂/光热试剂在肿瘤治疗中的应用研究进展[J]. 有机化学, 2020, 40(12): 4155-4167.

Wang Lingyun, Xin Shuqi, Tang Hao, Cao Derong. Research Progress in Cancer Treatment by Diketopyrrolopyrrole-Based Photosensitizers and Photothermal Agents[J]. Chinese Journal of Organic Chemistry, 2020, 40(12): 4155-4167.

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吡咯并吡咯二酮类光敏剂/光热试剂在肿瘤治疗中的应用研究进展

Research Progress in Cancer Treatment by Diketopyrrolopyrrole-Based Photosensitizers and Photothermal Agents

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