氟硼类荧光染料及其衍生物在肿瘤诊疗一体化中的应用

doi:10.6023/cjoc201812016

有机化学 ›› 2019, Vol. 39 ›› Issue (7): 1891-1912.DOI: 10.6023/cjoc201812016 上一篇下一篇

所属专题：荧光探针-生物传感合辑；有机超分子化学合辑

综述与进展

氟硼类荧光染料及其衍生物在肿瘤诊疗一体化中的应用

冯彤, 薛中博, 尹娟娟, 蒋旭, 冯亚青, 孟舒献

天津大学化工学院天津 300350

收稿日期:2018-12-10 修回日期:2019-01-06 发布日期:2019-02-19
通讯作者: 孟舒献 E-mail:msxmail@tju.edu.cn
基金资助:
国家自然科学基金（No.21676187）、中国国际科技计划（Nos.2012DFG41980，2016YFE0114900）资助项目.

Application of Fluoroboron Fluoresceins (BODIPYS) and Their Derivatives in the Synergistic Diagnosis and Treatment of Tumor

Feng Tong, Xue Zhongbo, Yin Juanjuan, Jiang Xu, Feng Yaqing, Meng Shuxian

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350

Received:2018-12-10 Revised:2019-01-06 Published:2019-02-19
Contact: 10.6023/cjoc201812016 E-mail:msxmail@tju.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21676187), and the China International Science and Technology Project (Nos. 2012DFG41980, 2016YFE0114900).

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摘要/Abstract

肿瘤是全世界发病率最高、死亡率最大的疾病之一.鉴于肿瘤的高风险与高死亡率，世界各地的研究人员致力于开发更精确快速的诊断策略和更有效的治疗方法来对抗，针对肿瘤的光学诊疗一体化技术应运而生.氟硼荧类化合物（BODIPY）因其优良的光学性质在肿瘤光诊疗中被广泛关注.详细介绍了BODIPY及其衍生物作为光敏剂、光热转化剂及显影剂在肿瘤诊疗（光动力治疗、光热治疗、光声成像）以及诊疗一体化中的应用，全面系统地评价了不同BODIPY结构以及其衍生物在肿瘤诊疗中的效果.这对于合理设计具有高单线态氧量子产率、高光热转化率以及良好的光稳定性和溶解性等优点的近红外BODIPY材料具有重要意义.

关键词: 肿瘤, BODIPY, 光动力治疗, 光热治疗, 光声成像, 协同诊疗

Tumor is one of the diseases with the highest mortality rate in the world. In view of the high risk and high mortality of tumor, researchers around the world are committed to develop more accurate and rapid diagnostic strategies and more effective treatments to fight tumor. Gradually, integrated optical diagnosis and treatment technologies for tumors have emerged. Fluoroboron fluorescein (BODIPY) has been widely used in tumor phototherapy because of its excellent optical properties. In this paper, BODIPY and its derivatives are introduced in detail as photosensitizers, photothermal transformants, and contrast agents in the diagnosis and treatment of tumors (photodynamic therapy, photothermal therapy, photoacoustic imaging) and integration of diagnosis and treatment. The effects of different BODIPY structures and their derivatives in tumor diagnosis and treatment were evaluated systematically. This is of great significance for the rational design of near-infrared BODIPY materials with high singlet oxygen quantum yield, high photothermal conversion, and good light stability and solubility.

Key words: tumor, BODIPY, photodynamic therapy, photothermal therapy, photoacoustic imaging, synergistic theranostics

引用此文

冯彤, 薛中博, 尹娟娟, 蒋旭, 冯亚青, 孟舒献. 氟硼类荧光染料及其衍生物在肿瘤诊疗一体化中的应用[J]. 有机化学, 2019, 39(7): 1891-1912.

Feng Tong, Xue Zhongbo, Yin Juanjuan, Jiang Xu, Feng Yaqing, Meng Shuxian. Application of Fluoroboron Fluoresceins (BODIPYS) and Their Derivatives in the Synergistic Diagnosis and Treatment of Tumor[J]. Chin. J. Org. Chem., 2019, 39(7): 1891-1912.

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氟硼类荧光染料及其衍生物在肿瘤诊疗一体化中的应用

Application of Fluoroboron Fluoresceins (BODIPYS) and Their Derivatives in the Synergistic Diagnosis and Treatment of Tumor

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