有机化学 ›› 2021, Vol. 41 ›› Issue (1): 258-266.DOI: 10.6023/cjoc202008045 上一篇    下一篇

研究论文

以氰甲基亚磷酸酯为含膦试剂的铜催化膦酰化异喹啉酮类化合物的高效合成

赵苏艳a,b, 宫雪芹c, 甘子玉c, 颜秋莉b, 刘学良d,*(), 杨道山b,c,*()   

  1. a 吉林警察学院实验技术中心 长春 130117
    b 青岛科技大学化学与分子工程学院 山东青岛 266042
    c 曲阜师范大学化学与化工学院 山东曲阜 273165
    d 新乡医学院基础医学院 河南新乡 453003
  • 收稿日期:2020-08-25 修回日期:2020-10-18 发布日期:2020-10-22
  • 通讯作者: 刘学良, 杨道山
  • 作者简介:
    * Corresponding authors. E-mail: ;
  • 基金资助:
    山东省自然科学基金(ZR2016JL012); 青岛科技大学高科技人才资助项目.

Efficient Copper-Catalyzed Domino Synthesis of Phosphonated Isoquinolin-1(2H)-ones Using Cyanomethylphosphonates as Building Blocks

Suyan Zhaoa,b, Xueqin Gongc, Ziyu Ganc, Qiuli Yanb, Xueliang Liud,*(), Daoshan Yangb,c,*()   

  1. a Experimental Technology Center, Jilin Police College, Changchun 130117
    b College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042
    c School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165
    d Basic Medical College, Xinxiang Medical University, Xinxiang, Henan 453003
  • Received:2020-08-25 Revised:2020-10-18 Published:2020-10-22
  • Contact: Xueliang Liu, Daoshan Yang
  • Supported by:
    the Natural Science Foundation of Shandong Province(ZR2016JL012); the Scientific Research Foundation of Qingdao University of Science and Technology.()

报道了一种铜催化“一锅法”高效合成膦酰化异喹啉酮类化合物的新方法. 该反应是第一例基于铜催化Ullmann偶联策略以氰甲基亚磷酸酯为含膦试剂制备含膦取代氮杂环化合物的新方法.

关键词: 铜催化, 异喹啉酮, 串联反应, 有机膦化合物

An efficient and convenient copper-catalyzed cascade synthesis of C-4 phosphonated isoquinolin-1(2 H)-ones has been initially proposed. This is the first example for the construction of phosphine-containing heterocycles through copper-catalyzed Ullmann-type coupling reactions using cyanomethylphosphonates as the building blocks, and it will broaden the strategies of organophosphorus synthesis in the field of organic and pharmaceutical chemistry.

Key words: copper-catalysis, isoquinolin-1(2 H)-one, tandem reaction, organophosphorus