有机化学 ›› 2021, Vol. 41 ›› Issue (5): 1804-1820.DOI: 10.6023/cjoc202010004 上一篇    下一篇

综述与进展

深海、沙漠、火山、极地来源链霉菌新天然产物(2009~2020)

江婷a, 蒲洪a, 段燕文a,b,c, 颜晓晖a,d, 黄勇a,c,*()   

  1. a 中南大学湘雅国际转化医学联合研究院 长沙 410013
    b 组合生物合成与天然产物药物湖南省工程研究中心 长沙 410011
    c 新药组合生物合成国家地方联合工程研究中心 长沙 410011
    d 天津中医药大学中医药研究院 天津 301617
  • 收稿日期:2020-10-05 修回日期:2020-11-24 发布日期:2020-12-19
  • 通讯作者: 黄勇
  • 基金资助:
    国家自然科学基金(81473124); 国家自然科学基金(81872779); 中南大学中央高校基本科研业务费专项资金(2019zzts774)

New Natural Products of Streptomyces Sourced from Deep-Sea, Desert, Volcanic, and Polar Regions from 2009 to 2020

Ting Jianga, Hong Pua, Yanwen Duana,b,c, Xiaohui Yana,d, Yong Huanga,c,*()   

  1. a Xiangya International Academy of Translational Medicine, Central South University, Changsha 410013
    b Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery, Changsha 410011
    c National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery, Changsha 410011
    d Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617
  • Received:2020-10-05 Revised:2020-11-24 Published:2020-12-19
  • Contact: Yong Huang
  • About author:
    * Corresponding author. E-mail:
  • Supported by:
    National Natural Science Foundation of China(81473124); National Natural Science Foundation of China(81872779); Fundamental Research Funds for the Central Universities of Central South University (CSU)(2019zzts774)

链霉菌是天然产物的重要来源, 但从土壤来源等普通生态环境筛选出的链霉菌中发现新化合物的比例有所降低. 深海、沙漠、火山或极地属于极端环境, 从中分离出的链霉菌因其特殊气候、地质或营养条件等的差异, 有可能产生较多新颖天然产物. 综述了2009年至2020年来从深海、沙漠、火山或极地链霉菌中发现的155个新天然产物, 介绍了它们的结构和生物活性.

关键词: 链霉菌, 深海, 火山, 沙漠, 天然产物, 生物活性

Streptomyces are important sources of natural products. However, it is more challenging to discover novel compounds from Streptomyces strains isolated from common environmental samples, such as typical soil samples. Due to the unique climates, varying geological and nutrition conditions, deep-sea, desert, volcanic and polar environments are extreme habitats for Streptomyces. These unique habitats are regarded as rare and under-explored niches of new Streptomyces strains and their natural products. The recent advancement of the structures and bioactivities of 155 natural products is reviewed, produced by various Streptomyces strains isolated from these extreme environments from 2009 to 2020.

Key words: Streptomyces, deep-sea, volcano sediments, desert, polar regions, natural products, biological activity