有机化学 ›› 2022, Vol. 42 ›› Issue (1): 257-265.DOI: 10.6023/cjoc202105025 上一篇    下一篇

研究论文

N-苯基丙烯酰胺与草氨酸衍生物的脱羧氨甲酰化反应研究

高启升, 荆祺, 陈阳, 孙京*(), 周明东*()   

  1. 辽宁石油化工大学石油化工学院 辽宁抚顺 113001
  • 收稿日期:2021-05-13 修回日期:2021-08-03 发布日期:2021-09-02
  • 通讯作者: 孙京, 周明东
  • 基金资助:
    辽宁省教育厅一般项目基金(L2019037)

Decarboxylative Amidation of Acrylamides with Oxamic Acids

Qisheng Gao, Qi Jing, Yang Chen, Jing Sun(), Mingdong Zhou()   

  1. School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun, Liaoning 113001
  • Received:2021-05-13 Revised:2021-08-03 Published:2021-09-02
  • Contact: Jing Sun, Mingdong Zhou
  • Supported by:
    Research Project Fund of Liaoning Provincial Department of Education(L2019037)

报道了一种银催化的N-苯基丙烯酰胺与N-取代草氨酸类衍生物的脱羧氨甲酰化反应, 通过分子间的氨甲酰自由基加成/环化过程, 能够以良好的产率制备一系列3,3-二取代的氨甲酰官能化的吲哚酮类化合物. 该反应具有广泛的官能团兼容性和良好的底物适用范围.

关键词: 氨甲酰化, 吲哚酮, 自由基加成环化

A silver catalyzed decaroxylative amidation of N-arylacrylamides with oxamic acids has been developed. This cascade reaction is an effective way to synthesize various 3,3-disubstitued amide functionalized oxindoles through a sequence of intermolecular carbamoyl radical addition and cyclization in moderate to good yields. This reaction allows a broad range of substrates as well as good functional group compatibility.

Key words: carbamoylation, oxindoles, radical addition cyclization