基于C—H键官能团化/环化串联策略构建吲哚酮分子骨架的研究进展

doi:10.6023/cjoc201601013

有机化学 ›› 2016, Vol. 36 ›› Issue (5): 875-888.DOI: 10.6023/cjoc201601013 上一篇下一篇

综述与进展

基于C—H键官能团化/环化串联策略构建吲哚酮分子骨架的研究进展

阿布力米提·阿布都卡德尔^a, 张永红^a, 张增鹏^a, 刘晨江^a,b

a. 新疆大学化学化工学院乌鲁木齐 830046;
b. 新疆大学理化测试中心乌鲁木齐 830046

收稿日期:2016-01-12 修回日期:2016-03-28 发布日期:2016-04-05
通讯作者: 刘晨江 E-mail:pxylcj@126.com
基金资助:
国家自然科学基金(Nos.21572195,21562039,21502162)资助项目.

Recent Advances of the Access to Indolinones via C—H Bond Functionalization/Cyclization Cascade Strategy

Abdukader Ablimit^a, Zhang Yonghong^a, Zhang Zengpeng^a, Liu Chenjiang ^a,b

a. School of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046;
b. Physics and Chemistry Detecting Center, Xinjiang University, Urumqi 830046

Received:2016-01-12 Revised:2016-03-28 Published:2016-04-05
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21572195, 21562039, 21502162).

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摘要/Abstract

吲哚酮尤其是3,3-二取代吲哚酮化合物具有重要的生物活性作用,其合成方法的研究已成为有机化学的热点领域.近年来,以N-芳基丙烯酰胺为起始原料,通过与自由基的加成、环化反应构建吲哚酮骨架的研究受到广泛关注.综述了基于C—H键官能团化/环化串联策略构建3,3-二取代吲哚酮骨架分子的研究进展,并对反应的机理进行了概括总结.

关键词: C—H活化, 吲哚酮, 串联反应

Due to the diverse biological activities of indolinones, especially 3,3-disubstituted indolinones, their researches of synthesis have been attracting considerable interest in the areas of organic chemistry. Recently, the radical addition and cyclization reaction of N-arylacrylamides with different radical precursors for the efficient construction of indolinones motifs have attracted much attention. This review summarizes the recent advances of the access to 3,3-disubstituted indolinones based on C—H bond functionalization/cyclization cascade strategy. These reaction mechanisms have also been introduced.

Key words: C—H functionalization, oxindoles, cascade reaction

引用此文

阿布力米提·阿布都卡德尔, 张永红, 张增鹏, 刘晨江. 基于C—H键官能团化/环化串联策略构建吲哚酮分子骨架的研究进展[J]. 有机化学, 2016, 36(5): 875-888.

Abdukader Ablimit, Zhang Yonghong, Zhang Zengpeng, Liu Chenjiang. Recent Advances of the Access to Indolinones via C—H Bond Functionalization/Cyclization Cascade Strategy[J]. Chin. J. Org. Chem., 2016, 36(5): 875-888.

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基于C—H键官能团化/环化串联策略构建吲哚酮分子骨架的研究进展

Recent Advances of the Access to Indolinones via C—H Bond Functionalization/Cyclization Cascade Strategy

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