有机化学 ›› 2022, Vol. 42 ›› Issue (8): 2515-2520.DOI: 10.6023/cjoc202203054 上一篇    下一篇

所属专题: 有机氟化学虚拟合辑

研究论文

镍催化炔烃的立体选择性芳基-二氟烷基化反应

孙奇, 孙泽颖, 俞泽, 王光伟*()   

  1. 天津大学理学院 天津 300350
  • 收稿日期:2022-03-28 修回日期:2022-04-24 发布日期:2022-05-06
  • 通讯作者: 王光伟

Nickel-Catalyzed Stereoselective Aryl-Difluoroalkylation of Alkynes

Qi Sun, Zeying Sun, Ze Yu, Guangwei Wang()   

  1. School of Science, Tianjin University, Tianjin 300350
  • Received:2022-03-28 Revised:2022-04-24 Published:2022-05-06
  • Contact: Guangwei Wang

报道了一种镍催化的炔烃的芳基-二氟烷基化反应. 从炔烃、溴二氟乙酸乙酯和芳基硼酸这些简单起始原料出发, 在镍络合物的催化下, 以高度立体选择性控制的方式得到一系列三取代含氟烯烃. 该方法具有催化剂成本低、反应条件温和、官能团兼容性好等优点.

关键词: 镍催化, 炔烃, 立体选择性, 芳基-二氟烷基化, 氟化学

A nickel-catalyzed aryl-difluoroalkylation of alkynes is developed. A series of trisubstituted fluoroalkenes can be obtained in a highly stereoselective manner by mixing of simple starting materials alkynes, ethyl bromodifluoroacetate, and arylboronic acids in the presence of nickel catalyst. This method features low-cost catalyst, mild reaction conditions, and excellent functional group compatibility.

Key words: nickel catalysis, alkynes, stereoselective, aryl-difluoroalkylation, fluorine chemistry