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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (4): 399-402. 上一篇    下一篇

研究论文

单手性臂脱氧胆酸分子裂缝的设计与微波合成

彭游, 牟其明, 杨祖幸, 顿珠次仁, 陈淑华*   

  1. 四川大学化学学院 成都 610064
  • 收稿日期:2003-06-30 修回日期:2003-09-23 接受日期:2003-10-15 发布日期:2022-09-19
  • 基金资助:
    国家自然科学基金(No. 20272038)资助项目

Design and Synthesis of Molecular Clefts with Only One Chiral Arm Derived fromCholic Acid under Microwave Irradiation

PENG, You, MU, Qi-Ming, YANG, Zu-Xing, DUNZHU, Ci-Ren, CHEN, Shu-Hua*   

  1. Faculty of Chemistry, Sichuan University, Chengdu 610064
  • Received:2003-06-30 Revised:2003-09-23 Accepted:2003-10-15 Published:2022-09-19
  • Contact: *E-mail: chemchensh@sina.com

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以脱氧胆酸甲酯为隔离基,3位构建为非手性单元,在12位引入手性单元,合成具有不同手性中心和裂穴的新型单手性臂分子裂缝受体.结构均经1H NMR, IR, MS及元素分析所确证,并且考察了其对中性小分子和D/L-氨基酸甲酯的识别性能.初步研究表明,这类裂缝型受体不仅对中性小分子具有优良的识别性能,而且对D/L-氨基酸甲酯具有良好的手性识别能力.

关键词: 脱氧胆酸, 微波辐射, 合成, 分子裂缝

A novel type of molecular cleft with one chiral armbased on deoxycholic acid has been synthesized under microwave irradiation. Thestructures of these new receptors were characterized by 1H NMR, IR, MS spectra and elemental analysis. Their recognition properties for neutral small moleculesand methyl esters of amino acids were investigated. The preliminary results indicate that these molecular clefts not only recognize neutral molecules, but alsoshow good enantio-selectivity for D/L-amino acid methyl esters.

Key words: deoxycholic acid, microwave irradiation, synthesis, molecular cleft