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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (12): 1637-1639. 上一篇    下一篇

研究简报

2,3-二取代-5-羟基苯并呋喃衍生物的合成

全哲山*, 赵立明, 李福男, 朴虎日   

  1. 延边大学医学院 延吉 133000
  • 收稿日期:2004-04-19 修回日期:2004-10-08 接受日期:2004-10-12 发布日期:2022-09-20

Synthesis of 2,3-Disubstituted-5-hydroxybenzofuran Derivatives

QUAN Zhe-Shan*, ZHAO Li-Ming, LI Fu-Nan, PIAO Hu-Ri   

  1. College of Pharmacy, Yanbian University, Yanji 133000
  • Received:2004-04-19 Revised:2004-10-08 Accepted:2004-10-12 Published:2022-09-20
  • Contact: *E-mail: quanzheshan@yahoo.com.cn

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用1,4-环己二酮与联二酮的缩合反应首次合成了4个未见文献报道的标题化合物,结构经IR, 1H NMR, MS和元素分析等测试确证,并对反应条件进行了初步探讨.结果表明,以LiCl作为催化剂,用1,3-二甲基-2-咪唑啉酮(DMI)为溶剂,于200 ℃反应1 h时收率最高.

关键词: 1,4-环己二酮, 2,3-丁二酮, 5-羟基-2,3-二甲基苯并呋喃, 合成

2,3-Disubstituted-5-hydroxybenzofurans were synthesized by the condensation of 1,4-cyclohexanedione with 1,2-diones. The structures of the target compoundswere confirmed by IR, 1H NMR and MS spectra. The reaction conditions werediscussed. The results showed that the condensation using LiCl as a catalyst, DMI as a solvent at 200 ℃ for 1 h gave the better yields.

Key words: 1,4-cyclohexanedione, 2,3-butanedione, 2,3-dimethyl-5-hydroxybenzofuran, synthesis