表皮生长因子受体的ATP竞争性抑制剂

有机化学 ›› 2004, Vol. 24 ›› Issue (12): 1640-1643. 上一篇

学术动态

表皮生长因子受体的ATP竞争性抑制剂

蒋毅, 郭宗儒^*

中国医学科学院中国协和医科大学药物研究所北京 100050

收稿日期:2003-09-08 修回日期:2004-03-08 接受日期:2004-06-11 发布日期:2022-09-20
基金资助:
国家科委863计划(No. 2002AA2Z3118)资助项目

ATP Competitive Inhibitors of Epidermal Growth Factor Receptor

JIANG Yi, GUO Zong-Ru^*

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking UnionMedical College, Beijing 100050

Received:2003-09-08 Revised:2004-03-08 Accepted:2004-06-11 Published:2022-09-20
Contact: *E-mail: jsnjcpuwubin@163.com

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摘要/Abstract

综述了表皮生长因子受体酪氨酸激酶的ATP竞争性抑制剂的研究进展,介绍了抑制剂结合受体蛋白的方式及其作用机理,重点介绍了可逆抑制剂和不可逆抑制剂的作用机理及其构效关系.

关键词: 表皮生长因子受体, EGFR, ATP竞争性抑制剂, 可逆抑制剂, 不可逆抑制剂

This article reviews the recent research progress in ATP competitive inhibitorsof epidermal growth factor receptor. The binding manner and inhibiting mechanismare introduced, with an emphasis on the mechanism and structure-activity relationship of both reversible and irreversible inhibitors.

Key words: epidermal growth factor receptor, EGFR, ATPcompetitive inhibitor, reversible inhibitor, irreversible inhibitor

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蒋毅, 郭宗儒. 表皮生长因子受体的ATP竞争性抑制剂[J]. 有机化学, 2004, 24(12): 1640-1643.

JIANG Yi, GUO Zong-Ru. ATP Competitive Inhibitors of Epidermal Growth Factor Receptor[J]. Chinese Journal of Organic Chemistry, 2004, 24(12): 1640-1643.

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表皮生长因子受体的ATP竞争性抑制剂

ATP Competitive Inhibitors of Epidermal Growth Factor Receptor

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