有机化学 ›› 2012, Vol. ›› Issue (03): 444-461.DOI: 10.6023/cjoc1108061 上一篇    下一篇

综述与进展

具有表皮生长因子受体抑制活性的喹唑啉衍生物研究进展

张英, 王培义, 胡德禹, 金林红, 杨松   

  1. 贵州大学精细化工研究中心 绿色农药与农业生物工程国家重点实验室培育基地与教育部重点实验室 贵阳 550025
  • 收稿日期:2011-08-06 修回日期:2011-10-10 发布日期:2012-03-24
  • 通讯作者: 杨松 E-mail:jhzx.msm@gmail. com
  • 基金资助:

    国家重点基础研究发展计划(973) (Nos. 2010CB126105, 2010CB134504)、国家自然科学基金(No. 21172048)和国家科技支撑计划课题(Nos.2011BAE06B02, 2011BAE06B05)资助项目.

Research Progress on Quinazoline Derivatives with Epidermal Growth Factor Receptor Inhibiting Bioactivity

Zhang Ying, Wang Peiyi, Hu Deyu, Jin Linhong, Yang Song   

  1. State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025
  • Received:2011-08-06 Revised:2011-10-10 Published:2012-03-24
  • Supported by:

    Project supported by the National Key Science Project for Basic Research (Nos. 2010CB126105, 2010CB134504), the National Natural Science Foundation of China (No. 21172048), and the National Key Technology Research & Development Program (Nos. 2011BAE06B02, 2011BAE06B05).

综述了近十年来具有表皮生长因子受体(EGFR)抑制活性的喹唑啉衍生物的国内外研究进展, 按照喹唑啉环上不同位置上的取代基类型分为四类, 介绍了化合物不同位置上取代基对此类化合物生物活性的影响, 并对其发展趋势和应用前景作了展望.

关键词: 表皮生长因子受体, 喹唑啉, 生物活性

The progress on quinazoline derivatives with epidermal growth factor receptor (EGFR) inhibiting bioactivity is reviewed in this paper. Quinazoline compounds are classified to four types according to different substituent groups at different ring position. The effects of substituent groups at different ring positions on the bioactivities are discussed. And the development tendency as well as the prospect of quinazoline derivatives as epidermal growth factor receptor tyrosine kinase inhibitors is summarized.

Key words: epidermal growth factor receptor, quinazoline, bioactivity