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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (7): 792-796. 上一篇    下一篇

研究论文

苯并咪唑类化合物一步法合成及表征

杨红伟a, 岳凡a, 封顺a, 王吉德*,a, 刘爱华a, 陈华梅a, 郁开北b   

  1. a新疆大学化学化工学院 乌鲁木齐 830046
    b中国科学院成都有机化学研究所 成都 610041
  • 收稿日期:2003-08-15 修回日期:2004-02-10 接受日期:2004-02-10 发布日期:2022-09-20
  • 通讯作者: *E-mail: awangjd@xju.edu.cn
  • 基金资助:
    教育部骨干教师计划资助项目

One-Step Synthesis and Characteristics of Benzimidazole Derivatives

YANG, Hong-Weia, YUE, Fana, FENG, Shuna, WANG, Ji-De*,a, LIU, Ai-Huaa, CHEN, Hua-Meia, YU, Kai-Beib   

  1. a College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046
    b Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041
  • Received:2003-08-15 Revised:2004-02-10 Accepted:2004-02-10 Published:2022-09-20

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采用对甲氧基苯甲醛、对羟基苯甲醛和邻苯二胺直接关环合成了1-(对甲氧基苄基)-2-(对甲氧基苯基)－苯并咪唑、1-(对羟基苄基)-2-(对羟基苯基)－苯并咪唑化合物.通过元素分析、IR、核磁分析对它们进行了表征,并培养了1-(对甲氧基苄基)-2-(对甲氧基苯基)－苯并咪唑化合物晶体.该晶体经X射线衍射确定为正交晶系,空间群Pna2(1), a=2.0194(7) nm, b=1.5657(4) nm, c=0.5498(1) nm, α=90°, β=90°, γ=90°, V=1.7383(8) nm3, Z=4, Mr=344.40, Dc=1.316 g/cm3, μ=0.85 cm－1, F(000)=728.

关键词: 苯并咪唑, 合成, 晶体结构

1-(p-Methoxybenzyl)-2-(p-methoxyphenyl)-benzimidazole or 1-(p-hydroxybenzyl)-2-(p-hydroxyphenyl)-benzimidazole was synthesized by the condensation of o-phenylenediamine with p-methoxybenzaldehyde or p-hydroxybenzaldehyde, and characterized byelemental analysis, IR and NMR spectra. Single crystals of 1-(p-methoxybenzyl)-2-(p-methoxyphenyl)benzimidazole were obtained. The crystal belongsto orthorhombic system, space group Pna2(1) with cell parameters: a=2.0194(7) nm, b=1.5657(4) nm, c=0.5498(1) nm, α=90°, β=90°, γ=90°, V=1.7383(8) nm3, Z=4, Mr=344.40, Dc=1.316 g/cm3, μ=0.85 cm－1, F(000)=728.

Key words: benzimidazole, synthesis, crystal structure