有机化学 ›› 2023, Vol. 43 ›› Issue (10): 3598-3607.DOI: 10.6023/cjoc202307030 上一篇    下一篇

所属专题: 有机硅化学专辑-2023

研究论文

铜催化双炔膦氧化物硅质子化反应合成β-硅基取代的乙烯基膦氧化物

陈志远, 杨梦维, 徐建林, 徐允河*()   

  1. 中国科学技术大学化学与材料科学学院 合肥 230026
  • 收稿日期:2023-07-31 修回日期:2023-09-06 发布日期:2023-09-08
  • 基金资助:
    国家自然科学基金(21871240); 及中央高校基本科研业务费专项资金(WK2060000017)

Regioselective Synthesis of β-Silyl-Substituted Vinylphosphine Oxides via Copper-Catalyzed Protosilylation of Dialkynylphosphine Oxides

Zhiyuan Chen, Mengwei Yang, Jianlin Xu, Yunhe Xu()   

  1. Department of Chemistry, University of Science and Technology of China, Hefei 230026
  • Received:2023-07-31 Revised:2023-09-06 Published:2023-09-08
  • Contact: *E-mail: xyh0709@ustc.edu.cn
  • Supported by:
    National Natural Science Foundation of China(21871240); Fundamental Research Funds for the Central Universities(WK2060000017)

报道了铜催化双炔基膦氧化物单侧硅质子化合成β-硅基取代乙烯基膦氧化物的反应. 各种(杂)芳基和烷基取代的二炔膦氧化物能够以中等和较高的产率和较高的化学选择性得到相应的目标产物. 产物中未反应的炔基可以被进一步衍生为其它官能团.

关键词: 铜催化剂, 硅质子化反应, 膦氧化合物, β-硅基取代化合物

A copper-catalyzed mono-lateral protosilylation of dialkynylphosphine oxides for the synthesis of β-silyl substituted vinylphosphine oxides is described. Various (hetero)aryl and alkyl-substituted diynes afforded the corresponding products in moderate and high yields with high chemoselectivity. An alternative alkynyl functional group of products could also be further derived.

Key words: copper catalyst, protosilylation, phosphine oxides, β-silyl substituted compounds