Green Synthesis of Pyrano[3,2-c]pyridine Derivatives in Ionic Liquids

doi:10.6023/cjoc201302019

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (08): 1728-1733.DOI: 10.6023/cjoc201302019 Previous Articles Next Articles

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离子液体中吡喃并[3,2-c]吡啶衍生物的绿色合成

张梅梅^a, 周玉静^b, 李玉玲^b, 刘蕴^b, 王香善^a,b

a 江苏师范大学江苏省药用植物生物技术重点实验室徐州 221116;
b 江苏师范大学化学化工学院徐州 221116

收稿日期:2013-02-26 修回日期:2013-04-09 发布日期:2013-04-17
通讯作者: 王香善 E-mail:xswang1974@yahoo.com
基金资助:
国家自然科学基金(Nos. 20802061, 21104064);青蓝工程基金(Nos. 10QLD008, GSFM2011003);江苏省高校产业化基金(No. JHB2012-31)资助项目.

Green Synthesis of Pyrano[3,2-c]pyridine Derivatives in Ionic Liquids

Zhang Meimei^a, Zhou Yujing^b, Li Yuling^b, Liu Yun^b, Wang Xiangshan^a,b

a Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Jiangsu Normal University, Xuzhou 221116;
b School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Received:2013-02-26 Revised:2013-04-09 Published:2013-04-17
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 20802061, 21104064), the Qing Lan Project (Nos. 10QLD008, GSFM2011003) and the College Industrialization Project (No. JHB2012-31) of Jiangsu Province.

A green and facile method for the synthesis of tert-butyl 2-amino-4-aryl-7,8-dihydro-5-oxo-4H-pyrano-[3,2-c]pyridine-6(5H)-carboxylate derivatives, is described in good to high yields using ionic liquids as green media. The method involves a three-component reaction of aromatic aldehyde, malononitrile or cyanacetate and tert-butyl 2,4-dioxopiperidine-1-carboxylate.

Key words: pyranopyridine, malononitrile, ionic liquid, synthesis

Cite this article

Zhang Meimei, Zhou Yujing, Li Yuling, Liu Yun, Wang Xiangshan. Green Synthesis of Pyrano[3,2-c]pyridine Derivatives in Ionic Liquids[J]. Chin. J. Org. Chem., 2013, 33(08): 1728-1733.

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离子液体中吡喃并[3,2-c]吡啶衍生物的绿色合成

Green Synthesis of Pyrano[3,2-c]pyridine Derivatives in Ionic Liquids

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