Copper-Catalyzed Microwave-Assisted Synthesis of Benzothiazole Derivatives in Water

doi:10.6023/cjoc201306044

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (12): 2559-2564.DOI: 10.6023/cjoc201306044 Previous Articles Next Articles

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水相中铜催化微波辅助合成苯并噻唑类衍生物的研究

柯方^a, 吴雯^b, 林晨^a, 李鹏^a

a 福建医科大学药学院福州 350004;
b 厦门市妇幼保健院厦门 361003

收稿日期:2013-06-30 修回日期:2013-07-17 发布日期:2013-08-13
通讯作者: 柯方 E-mail:kefang612@163.com
基金资助:
国家自然科学基金(No. 81202560)和福建省自然科学基金(No. 2012J05150)资助项目.

Copper-Catalyzed Microwave-Assisted Synthesis of Benzothiazole Derivatives in Water

Ke Fang^a, Wu Wen^b, Lin Chen^a, Li Peng^a

a Department of Pharmacy, Fujian Medical University, Fuzhou 350004;
b Xiamen Maternity and Child Care Hospital, Xiamen 361003

Received:2013-06-30 Revised:2013-07-17 Published:2013-08-13
Supported by:
Project supported by the National Natural Science Foundation of China (No. 81202560) and the Natural Science Foundation of Fujian Province (No. 2012J05150).

1. Copper-Catalyzed Microwave-Assisted Synthesis of Benzothiazole Derivatives in Water.PDF(720KB)

Abstract

A simple, efficient, inexpensive and powerful microwave-assisted method for the coupling of 2-iodoanilines with aldehydes was developed by using cheap CuI as catalyst, inexpensive and readily available 8-hydroxyquinoline as ligand, water as solvent at 100 ℃. Most target products were obtained in high yields.

Key words: microwave-assisted synthesis, 2-iodoanilines, aldehydes, benzothiazoles, potassium thiocyanate

Cite this article

Ke Fang, Wu Wen, Lin Chen, Li Peng. Copper-Catalyzed Microwave-Assisted Synthesis of Benzothiazole Derivatives in Water[J]. Chin. J. Org. Chem., 2013, 33(12): 2559-2564.

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水相中铜催化微波辅助合成苯并噻唑类衍生物的研究

Copper-Catalyzed Microwave-Assisted Synthesis of Benzothiazole Derivatives in Water

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