Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (3): 589-595.DOI: 10.6023/cjoc201309010 Previous Articles     Next Articles

Notes

蒽醌-多胺缀合物的合成及生理活性研究

甘莹, 何利华, 张亚宏, 王建红, 赵瑾   

  1. 河南大学 河南省天然药物与免疫工程重点实验室 开封 475004
  • 收稿日期:2013-09-16 修回日期:2013-10-24 发布日期:2013-11-20
  • 通讯作者: 王建红,赵瑾 E-mail:hdky@henu.edu.cn
  • 基金资助:

    国家自然科学基金(No. 21272056);河南省科技厅(Nos. 112300413224,132300410228)资助项目.

Synthesis and Biological Activity of Anthraquinone-polyamine Derivatives

Gan Ying, He Lihua, Zhang Yahong, Wang Jianhong, Zhao Jin   

  1. Key Laboratory of Natural Medicines and Immunotechnology of Henan Province, Henan University, Kaifeng 475004
  • Received:2013-09-16 Revised:2013-10-24 Published:2013-11-20
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21272056) and the Key Scientific and Technological Projects of Henan Province (Nos. 112300413224, 132300410228).

Seven anthraquinone-polyamine derivatives were designed and synthesized. The structures of the synthesized compounds were confirmed by 1H NMR, APCI-MS and elemental analysis. Prelimilary antitumor activity was invesitgated on K562, HepG2, MB231, Hela and HCT-116 cell lines by MTT (thiazolyl blue) assay. The results indicated that the target compounds obviously exhibited antitumor activity against the tested cell lines. Compounds 11b and 14c can intercalate to DNA with intensively fluorescence quenching in herring sperm DNA-EB system.

Key words: nitrogen mustard derivatives, synthesis, biological activity, DNA intercalator