Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (6): 1479-1486.DOI: 10.6023/cjoc201611031 Previous Articles     Next Articles



张自鹏, 杨新颖, 方浩   

  1. 山东大学药学院 济南 250012
  • 收稿日期:2016-11-23 修回日期:2017-01-03 发布日期:2017-02-08
  • 通讯作者: 方浩
  • 基金资助:


Synthesis and Antiproliferative Activity of Novel Purin-8-one Derivatives

Zhang Zipeng, Yang Xinying, Fang Hao   

  1. School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012
  • Received:2016-11-23 Revised:2017-01-03 Published:2017-02-08
  • Contact: 10.6023/cjoc201611031
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21672127).

A series of novel purin-8-one derivatives were prepared with the starting materials of 2,4-dichloro-5-nitropyrimidine and followed by multi-step reactions. The structures of all target compounds were identified by 1H NMR, 13C NMR and HRMS. The preliminary biological evaluations were performed using thiazolyl blue tetrazolium bromide (MTT) method to test their antiproliferative activities against some tumor cell lines. The results suggested that some compounds exhibited good anti-proliferative activities against tumor cell lines. Especially, four compounds showed similar or better inhibitory activities against Hela, MOLT-4 and K562 tumor cell lines compared with R-roscovitine.

Key words: purine derivatives, antitumor, synthesis