Synthesis and Biological Activities of Novel Pyrazole Amide Derivatives Containing Substituted Isoxazole Group

doi:10.6023/cjoc201702025

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (8): 2165-2171.DOI: 10.6023/cjoc201702025 Previous Articles Next Articles

Notes

新型含取代异噁唑结构的吡唑酰胺类衍生物的合成及其生物活性研究

戴红^a, 姚炜^a, 叶林玉^a, 方源^b, 石玉军^a,b, 宋婵^a, 李春建^c, 石健^c

a 南通大学化学化工学院南通 226019;
b 江苏科技大学环境与化学工程学院镇江 212003;
c 南通大学分析测试中心南通 226019

收稿日期:2017-02-19 修回日期:2017-03-09 发布日期:2017-04-01
通讯作者: 石玉军, 石健 E-mail:yjshi2015@163.com;gaohbhe2015@aliyun.com
基金资助:
国家自然科学基金（No.21372135）、江苏省“六大人才高峰”（No.2013-SWYY-013）、南通市科技计划（No.MS22015020）和江苏省研究生实践创新计划（No.SJCX17_0640）资助项目.

Synthesis and Biological Activities of Novel Pyrazole Amide Derivatives Containing Substituted Isoxazole Group

Dai Hong^a, Yao Wei^a, Ye Linyu^a, Fang Yuan^b, Shi Yujun^a,b, Song Chan^a, Li Chunjian^c, Shi Jian^c

a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
b School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003;
c Analysis and Testing Center, Nantong University, Nantong 226019

Received:2017-02-19 Revised:2017-03-09 Published:2017-04-01
Contact: 10.6023/cjoc201702025 E-mail:yjshi2015@163.com;gaohbhe2015@aliyun.com
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), the Science and Technology Project Fund of Nantong City (No. MS22015020), and the Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. SJCX17_0640).

1. Synthesis and Biological Activities of Novel Pyrazole Amide Derivatives Containing Substituted Isoxazole Group.PDF(907KB)

Abstract

In order to find novel pyrazole compounds possessing potent biological activities, a series of novel pyrazole amide derivatives bearing substituted isoxazole moiety were designed and synthesized according to the method of active substructure combination. Their structures were confirmed by ¹H NMR, ¹³C NMR and elemental analysis. The bioassay data indicated that some title compounds had good insecticidal activities. At the concentration of 500 μg/mL, some compounds showed 60%~100% insecticidal activity against Oriental armyworm, and 50%~100% insecticidal activity against Aphis medicaginis. Additionally, some compounds exhibited good anti-cancer activity against HepG2 cells with the IC₅₀ values of 14.2~18.9 μmol/L.

Key words: isoxazole, pyrazole, amide, synthesis, biological activity

Cite this article

Dai Hong, Yao Wei, Ye Linyu, Fang Yuan, Shi Yujun, Song Chan, Li Chunjian, Shi Jian. Synthesis and Biological Activities of Novel Pyrazole Amide Derivatives Containing Substituted Isoxazole Group[J]. Chin. J. Org. Chem., 2017, 37(8): 2165-2171.

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新型含取代异噁唑结构的吡唑酰胺类衍生物的合成及其生物活性研究

Synthesis and Biological Activities of Novel Pyrazole Amide Derivatives Containing Substituted Isoxazole Group

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