Design, Synthesis and Application of Fluorescence Resonance Energy Transfer-Based Ratiometric Hydrazine Fluorescent Probe

doi:10.6023/cjoc201811034

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (5): 1483-1488.DOI: 10.6023/cjoc201811034 Previous Articles Next Articles

Special Issue: 荧光探针-生物传感合辑；有机超分子化学合辑

Notes

基于荧光共振能量转移效应的比例计量型水合肼荧光探针的设计、合成及其应用研究

杨滋琦^a, 刘兴坤^b, 姜鲁南^b, 王美^a

a 河北大学化学与环境科学学院保定 071002;
b 河北大学药学院保定 071002

收稿日期:2018-11-28 修回日期:2019-01-07 发布日期:2019-01-18
通讯作者: 王美 E-mail:wangmarian@163.com
基金资助:
国家自然科学基金（No.51578067）、河北省自然科学基金（No.2018201234）、河北省高等学校科学技术研究项目（No.QN2017015）和保定市科学研究与发展计划（Nos.16zg031，18ZF315）资助项目.

Design, Synthesis and Application of Fluorescence Resonance Energy Transfer-Based Ratiometric Hydrazine Fluorescent Probe

Yang Ziqi^a, Liu Xingkun^b, Jiang Lu'nan^b, Wang Mei^a

a College of Chemistry and Environmental Science, Hebei University, Baoding 071002;
b College of Pharmacy, Hebei University, Baoding 071002

Received:2018-11-28 Revised:2019-01-07 Published:2019-01-18
Contact: 10.6023/cjoc201811034 E-mail:wangmarian@163.com
Supported by:
Project supported by the National Natural Scinec Foundation of China (No. 51578067), the Natural Science Foundation of Hebei Provience (No. 2018201234), the Colleges and Universities Science Technology Research Project of Hebei Province (No. QN2017015) and the Science Technology Research and Development Guidance Programme Project of Baoding City (Nos. 16zg031, 18ZF315).

1. Design, Synthesis and Application of Fluorescence Resonance Energy Transfer-Based Ratiometric Hydrazine Fluorescent Probe.PDF(3321KB)

Abstract

Hydrazine (N₂H₄) is a highly toxic biochemical reagent with the capability of mutagenic, teratogenic and carcinogenic. For accurately monitoring the concentration of N₂H₄ in the environment and life, two FRET (fluorescence resonance energy transfer)-based dual-emissive ratiometric fluorescent probes (FRET-1/2) were designed and synthesized. The structures of both probes were charactered by ¹H NMR, ¹³C NMR and HRMS. The results prove that both probes exhibit good selectivity and sensitivity to N₂H₄ and can be used for detecting N₂H₄ in water samples.

Key words: hydrazine, fluorescence resonance energy transfer (FRET), ratiometric, fluorescent probe

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Yang Ziqi, Liu Xingkun, Jiang Lu'nan, Wang Mei. Design, Synthesis and Application of Fluorescence Resonance Energy Transfer-Based Ratiometric Hydrazine Fluorescent Probe[J]. Chin. J. Org. Chem., 2019, 39(5): 1483-1488.

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基于荧光共振能量转移效应的比例计量型水合肼荧光探针的设计、合成及其应用研究

Design, Synthesis and Application of Fluorescence Resonance Energy Transfer-Based Ratiometric Hydrazine Fluorescent Probe

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