Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (2): 408-416.DOI: 10.6023/cjoc201907026 Previous Articles     Next Articles


林伟, 庄苍伟, 胡秀秀, 杨凤丽   

  1. 江苏理工学院化学与环境工程学院 江苏常州 213001
  • 收稿日期:2019-07-19 修回日期:2019-08-25 发布日期:2019-10-25
  • 通讯作者: 林伟, 杨凤丽;
  • 基金资助:

Efficient Synthesis of Coumarin-Fused Pyrazolo[3,4-b]pyridine Derivatives Catalyzed by Niobic Acid Modified with Phosphoric Acid under Microwave Irradiation

Lin Wei, Zhuang Cangwei, Hu Xiuxiu, Yang Fengli   

  1. School of Chemistry and Environmental Engineering, Jiangsu Techology of University, Changzhou, Jiangsu 213001
  • Received:2019-07-19 Revised:2019-08-25 Published:2019-10-25
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21502074), the Qing Lan Project of Jiangsu Province and the Postgraduate Research & Practice Innovation Program of Jiangsu Province (No. SJCX19_0766).

Coumarin and pyrazolo[3,4-b]pyridine are structurally essential elements in biologically active natural compounds and are extremely important in medicinal chemistry by serving as key pharmacophores in drug discovery. In this article, the efficient synthesis of coumarin-fused pyrazolo[3,4-b]pyridine via three-component domino reaction of aldehydes, coumarin derivative and 5-aminopyrazole in one step catalyzed by niobic acid modified with phosphoric acid under microwave irradiation has been achieved. The one-pot procedure, eco-friendly catalyst and solvent as well as simple operation are the key features of this method. The structures of the products were identified by IR, NMR, and HRMS spectra.

Key words: coumarin, pyrazolo[3,4-b]pyridine, synthesis, niobic acid