Bifunctional Phosphine Ligand-Enabled Gold(I)-Catalyzed Efficient Synthesis of 1,5-Benzodiazepines

doi:10.6023/cjoc202003024

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (8): 2520-2525.DOI: 10.6023/cjoc202003024 Previous Articles Next Articles

双官能膦配体-金(I)高效催化合成1,5-苯并二氮（艹卓）

郑康河, 周丙伟, 金红卫, 刘运奎

浙江工业大学化学工程学院绿色化学与技术国家重点实验室培育基地杭州 310014

收稿日期:2020-03-09 修回日期:2020-05-28 发布日期:2020-06-10
通讯作者: 刘运奎 E-mail:ykuiliu@zjut.edu.cn
基金资助:
国家自然科学基金（Nos.21772176，21372201）和浙江省自然科学基金（No.LY20B020013）资助项目.

Bifunctional Phosphine Ligand-Enabled Gold(I)-Catalyzed Efficient Synthesis of 1,5-Benzodiazepines

Zheng Kanghe, Zhou Bingwei, Jin Hongwei, Liu Yunkui

State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Received:2020-03-09 Revised:2020-05-28 Published:2020-06-10
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21772176, 21372201), and the Natural Science Foundation of Zhejiang Province (No. LY20B020013).

1. cjoc202003024.pdf(2158KB)

Abstract

At room temperature, a bifunctional phosphine-gold(I) catalyst was used to catalyze the nucleophilic addition/cyclization reaction of o-phenylenediamines with alkynes to generate 1,5-benzodiazepines in one step. The reaction has the advantages of high atomic-economy, simple raw materials, convenient operation and mild reaction conditions.

Key words: phthaline diamine, alkyne, bifunctional phosphine ligand, gold catalysis, 1,5-benzodiazepine

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Zheng Kanghe, Zhou Bingwei, Jin Hongwei, Liu Yunkui. Bifunctional Phosphine Ligand-Enabled Gold(I)-Catalyzed Efficient Synthesis of 1,5-Benzodiazepines[J]. Chinese Journal of Organic Chemistry, 2020, 40(8): 2520-2525.

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双官能膦配体-金(I)高效催化合成1,5-苯并二氮（艹卓）

Bifunctional Phosphine Ligand-Enabled Gold(I)-Catalyzed Efficient Synthesis of 1,5-Benzodiazepines

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