Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (8): 2520-2525.DOI: 10.6023/cjoc202003024 Previous Articles     Next Articles


郑康河, 周丙伟, 金红卫, 刘运奎   

  1. 浙江工业大学化学工程学院 绿色化学与技术国家重点实验室培育基地 杭州 310014
  • 收稿日期:2020-03-09 修回日期:2020-05-28 发布日期:2020-06-10
  • 通讯作者: 刘运奎
  • 基金资助:

Bifunctional Phosphine Ligand-Enabled Gold(I)-Catalyzed Efficient Synthesis of 1,5-Benzodiazepines

Zheng Kanghe, Zhou Bingwei, Jin Hongwei, Liu Yunkui   

  1. State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2020-03-09 Revised:2020-05-28 Published:2020-06-10
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21772176, 21372201), and the Natural Science Foundation of Zhejiang Province (No. LY20B020013).

At room temperature, a bifunctional phosphine-gold(I) catalyst was used to catalyze the nucleophilic addition/cyclization reaction of o-phenylenediamines with alkynes to generate 1,5-benzodiazepines in one step. The reaction has the advantages of high atomic-economy, simple raw materials, convenient operation and mild reaction conditions.

Key words: phthaline diamine, alkyne, bifunctional phosphine ligand, gold catalysis, 1,5-benzodiazepine