Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (11): 3672-3685.DOI: 10.6023/cjoc202006076 Previous Articles     Next Articles

Special Issue: 创刊四十周年专辑


唐雨平a,b, 何艳梅a, 范青华a,b   

  1. a 中国科学院化学研究所 中国科学院分子识别与功能重点实验室 北京分子科学国家研究中心 北京 100190;
    b 中国科学院大学化学科学学院 北京 100049
  • 收稿日期:2020-06-30 修回日期:2020-08-03 发布日期:2020-08-11
  • 通讯作者: 何艳梅, 范青华;
  • 基金资助:

Artificial Stimuli-Responsive Catalytic Systems for Switchable Asymmetric Catalysis

Tang Yupinga,b, He Yanmeia, Fan Qinghuaa,b   

  1. a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences(CAS), Beijing 100190;
    b School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049
  • Received:2020-06-30 Revised:2020-08-03 Published:2020-08-11
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21772204, 21521002), and the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (No. QYZDJ-SSW-SLH023).

Inspired by enzyme allosteric catalysis, the study on artificial stimuli-responsive asymmetric catalytic systems has attracted more and more attentions in recent years. In order to precisely control the catalytic activity and stereoselectivity, stimuli-responsive functionalities have been introduced into the catalyst design. A variety of asymmetric reactions featuring on/off-switchable catalysis and/or stereodivergent catalysis have been successfully achieved by using light-, coordination-, pH-and redox-driven chiral switchable catalysts. By selecting representative examples, the catalyst design principles, allosteric mechanism and their applications in switchable asymmetric reactions sre mainly introduced. At the same time, advantages and limitations of this emerging field are summarized, and perspectives for its future development are given.

Key words: asymmetric catalysis, stimuli-responsiveness, chiral switchable catalyst, allosteric catalysis, enantiodivergent catalysis