Visible-Light-Induced Selective Hydrocarboxylation of Alkynes with Formate

doi:10.6023/cjoc202405025

Abstract

Herein, we disclosed an efficient and sustainable protocol for regioselective hydrocarboxylation of alkynes to construct diverse propionic acid derivatives. Under photoinduced conditions, the anti-Markovnikov hydrocarboxylation of alkynes was realized with CO₂ radical anion in-situ generated from formate as both a carbonyl source and a reductant. The collaboration between photosensitizer and hydrogen atom transfer catalyst promoted the catalytic cycle to work smoothly, giving a broad substrate scope including terminal and internal alkynes. The Giese radical addition of CO₂ radical anion to the C-C triple bond is the key step to initiate the reaction.

Key words: formate, CO₂ radical anion, hydrocarboxylation, visible-light catalysis, aryl propionic acids

Cite this article

Xu Hui, Jiang Hui-Xian, Kan Lei, Xu Pei, Zhu Xu. Visible-Light-Induced Selective Hydrocarboxylation of Alkynes with Formate[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202405025.

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