Recent Advances on the Synthesis of Spirofluorene-based Compounds

doi:10.6023/cjoc202507025

Chinese Journal of Organic Chemistry

REVIEW

螺芴基化合物的合成研究进展

韦翠, 刘金秋, 邓灿, 邹宁^*, 周文俊^*

内江师范学院化学与环境工程学院(沱江流域特色农业资源四川省科技资源共享服务平台), 内江, 641100

收稿日期:2025-07-19 修回日期:2025-10-26
基金资助:
四川省自然科学基金(No. 2024NSFSC1127、2024NSFSC0284); 精细化工助剂及表明活性剂四川省高校重点实验室开放基金(No. 2024JXY06); 内江师范学院校级科研重点项目(2024ZDZ01); 大学生创新创业训练计划项目(X2024014)资助项目

Recent Advances on the Synthesis of Spirofluorene-based Compounds

Wei Cui, Liu Jinqiu, Deng Can, Zou Ning^*, Zhou Wenjun^*

School of Chemical and Environmental Engineering, Neijiang Normal University (Special Agricultural Resources in Tuojiang River Basin Sharing and Service Platform of Sichuan Province), Neijiang 641100, China

Received:2025-07-19 Revised:2025-10-26
Contact: *E-mail: chemzhwj@126.com; Zningzou@163.com
Supported by:
Natural Science Foundation of Sichuan (No. 2024NSFSC1127、2024NSFSC0284); the Open Fund of Key Laboratory of Fine Chemical Additives and Surfactants, Sichuan Provincial Universities (No. 2024JXY06); the Key Research Project of Neijiang Normal University (No. 2024ZDZ01); Innovation and Entrepreneurship Training Program (No. X2024014).

Spirofluorene-based skeletons, widely found in biologically active molecules and various functional materials, represent a privileged scaffold in pharmaceutical and optoelectronic design due to their unique rigidity and stability, which lead to improve device luminescence efficiency, thermal stability and chemical stability Nevertheless, the efficient synthesis of these compounds remains challenging owing to the steric hindrance and rigidity inherent to their spirocyclic architecture. This review focuses on new strategies and methods developed over the past decade for the synthesis of spirofluorene-based compounds, including cyclization, cycloaddition, and C-H activation reactions, aiming to provide insights for the efficient preparation of related structures.

Key words: Spirofluorene-based compounds, Spirocyclic compounds, Cycloaddition, Cyclization, C-H Activation

Cite this article

Wei Cui, Liu Jinqiu, Deng Can, Zou Ning, Zhou Wenjun. Recent Advances on the Synthesis of Spirofluorene-based Compounds[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202507025.

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螺芴基化合物的合成研究进展

Recent Advances on the Synthesis of Spirofluorene-based Compounds

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